PMID- 29375338
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 11
DP  - 2017
TI  - Characteristics of Resting-State Functional Connectivity in Intractable 
      Unilateral Temporal Lobe Epilepsy Patients with Impaired Executive Control 
      Function.
PG  - 609
LID - 10.3389/fnhum.2017.00609 [doi]
LID - 609
AB  - Executive control function (ECF) deficit is a common complication of temporal 
      lobe epilepsy (TLE). Characteristics of brain network connectivity in TLE with 
      ECF dysfunction are still unknown. The aim of this study was to investigate 
      resting-state functional connectivity (FC) changes in patients with unilateral 
      intractable TLE with impaired ECF. Forty right-handed patients with left TLE 
      confirmed by comprehensive preoperative evaluation and postoperative pathological 
      findings were enrolled. The patients were divided into normal ECF (G1) and 
      decreased ECF (G2) groups according to whether they showed ECF impairment on the 
      Wisconsin Card Sorting Test (WCST). Twenty-three healthy volunteers were 
      recruited as the healthy control (HC) group. All subjects underwent resting-state 
      functional magnetic resonance imaging (rs-fMRI). Group-information-guided 
      independent component analysis (GIG-ICA) was performed to estimate resting-state 
      networks (RSNs) for all subjects. General linear model (GLM) was employed to 
      analyze intra-network FC (p < 0.05, false discovery rate, FDR correction) and 
      inter-network FC (p < 0.05, Bonferroni correction) of RSN among three groups. 
      Pearson correlations between FC and neuropsychological tests were also determined 
      through partial correlation analysis (p < 0.05). Eleven meaningful RSNs were 
      identified from 40 left TLE and 23 HC subjects. Comparison of intra-network FC of 
      all 11 meaningful RSNs did not reveal significant difference among the three 
      groups (p > 0.05, FDR correction). For inter-network analysis, G2 exhibited 
      decreased FC between the executive control network (ECN) and default-mode network 
      (DMN) when compared with G1 (p = 0.000, Bonferroni correction) and HC (p = 0.000, 
      Bonferroni correction). G1 showed no significant difference of FC between ECN and 
      DMN when compared with HC. Furthermore, FC between ECN and DMN had significant 
      negative correlation with perseverative responses (RP), response errors (RE) and 
      perseverative errors (RPE) and had significant positive correlation categories 
      completed (CC) in both G1 and G2 (p < 0.05). No significant difference of 
      Montreal Cognitive Assessment (MoCA) was found between G1 and G2, while 
      intelligence quotient (IQ) testing showed significant difference between G1and 
      G2.There was no correlation between FC and either MoCA or IQ performance. Our 
      findings suggest that ECF impairment in unilateral TLE is not confined to the 
      diseased temporal lobe. Decreased FC between DMN and ECN may be an important 
      characteristic of RSN in intractable unilateral TLE.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Capital Medical University, Beijing, China.
FAU - Yang, Hongyu
AU  - Yang H
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Capital Medical University, Beijing, China.
FAU - Qin, Wen
AU  - Qin W
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Liu, Chang
AU  - Liu C
AD  - Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical 
      University, Beijing, China.
FAU - Qi, Zhigang
AU  - Qi Z
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Capital Medical University, Beijing, China.
FAU - Chen, Nan
AU  - Chen N
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Capital Medical University, Beijing, China.
FAU - Li, Kuncheng
AU  - Li K
AD  - Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, 
      Capital Medical University, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20171213
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC5770650
OTO - NOTNLM
OT  - Wisconsin Card Sorting Test
OT  - executive control function
OT  - functional connectivity
OT  - independent component analysis
OT  - resting-state networks
OT  - temporal lobe epilepsy
EDAT- 2018/01/30 06:00
MHDA- 2018/01/30 06:01
PMCR- 2017/01/01
CRDT- 2018/01/30 06:00
PHST- 2017/06/17 00:00 [received]
PHST- 2017/11/28 00:00 [accepted]
PHST- 2018/01/30 06:00 [entrez]
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2018/01/30 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2017.00609 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2017 Dec 13;11:609. doi: 10.3389/fnhum.2017.00609. 
      eCollection 2017.