PMID- 29375818
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201214
IS  - 2046-1402 (Print)
IS  - 2046-1402 (Electronic)
IS  - 2046-1402 (Linking)
VI  - 7
DP  - 2018
TI  - Molecular mechanisms of macrophage Toll-like receptor-Fc receptor synergy.
PG  - 21
LID - 10.12688/f1000research.12679.1 [doi]
LID - 21
AB  - Macrophages (MOs) are a key cell type of both the innate and the adaptive immune 
      response and can tailor their response to prevailing conditions. To sense the 
      host's status, MOs employ two classes of receptors: Toll-like receptors (TLRs), 
      which are sensors for pathogen-derived material, and Fcgamma receptors (FcgammaRs) that 
      are detectors of the adaptive immune response. How MOs integrate the input from 
      these various sensors is not understood and is the focus of active study. Here, 
      we review the recent literature on the molecular mechanisms of TLR and FcgR 
      crosstalk and synergy, and discuss the implications of these findings. This 
      overview suggests a multilayered mechanism of receptor synergy that allows the MO 
      to fine-tune its response to prevailing conditions and provides ideas for future 
      investigation.
FAU - Lennartz, Michelle
AU  - Lennartz M
AD  - Department of Regenerative and Cancer Cell Biology, Albany Medical College, 47 
      New Scotland Avenue, Albany, NY, 12008, USA.
FAU - Drake, James
AU  - Drake J
AUID- ORCID: 0000-0001-7675-6443
AD  - Department of Immunology and Microbial Disease, Albany Medical College, 47 New 
      Scotland Avenue, Albany, NY, 12008, USA.
LA  - eng
GR  - R03 AI056321/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180108
PL  - England
TA  - F1000Res
JT  - F1000Research
JID - 101594320
PMC - PMC5760967
OTO - NOTNLM
OT  - Fc receptors
OT  - Macrophages
OT  - toll-like receptors
COIS- No competing interests were disclosed.No competing interests were disclosed.No 
      competing interests were disclosed.
EDAT- 2018/01/30 06:00
MHDA- 2018/01/30 06:01
PMCR- 2018/01/08
CRDT- 2018/01/30 06:00
PHST- 2017/12/15 00:00 [accepted]
PHST- 2018/01/30 06:00 [entrez]
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2018/01/30 06:01 [medline]
PHST- 2018/01/08 00:00 [pmc-release]
AID - 10.12688/f1000research.12679.1 [doi]
PST - epublish
SO  - F1000Res. 2018 Jan 8;7:21. doi: 10.12688/f1000research.12679.1. eCollection 2018.