PMID- 29376234
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20240124
IS  - 2162-0989 (Electronic)
IS  - 2162-0989 (Linking)
VI  - 7
IP  - 1
DP  - 2018 Jan-Feb
TI  - Multimodal Imaging in Diabetic Macular Edema.
PG  - 22-27
LID - 10.22608/APO.2017504 [doi]
AB  - Throughout ophthalmic history it has been shown that progress has gone hand in 
      hand with technological breakthroughs. In the past, fluorescein angiography and 
      fundus photographs were the most commonly used imaging modalities in the 
      management of diabetic macular edema (DME). Today, despite the moderate 
      correlation between macular thickness and functional outcomes, spectral domain 
      optical coherence tomography (SD-OCT) has become the DME workhorse in clinical 
      practice. Several SD-OCT biomarkers have been looked at including presence of 
      epiretinal membrane, vitreomacular adhesion, disorganization of the inner retinal 
      layers, central macular thickness, integrity of the ellipsoid layer, and 
      subretinal fluid, among others. Emerging imaging modalities include fundus 
      autofluorescence, macular pigment optical density, fluorescence lifetime imaging 
      ophthalmoscopy, OCT angiography, and adaptive optics. Technological advances in 
      imaging of the posterior segment of the eye have enabled ophthalmologists to 
      develop hypotheses about pathological mechanisms of disease, monitor disease 
      progression, and assess response to treatment. Spectral domain OCT is the most 
      commonly performed imaging modality in the management of DME. However, reliable 
      biomarkers have yet to be identified. Machine learning may provide treatment 
      algorithms based on multimodal imaging.
CI  - Copyright 2018 Asia-Pacific Academy of Ophthalmology.
FAU - Acon, Dhariana
AU  - Acon D
AD  - Asociacion para Evitar la Ceguera, Hospital Luis Sanchez Bulnes. Mexico City, 
      Mexico.
FAU - Wu, Lihteh
AU  - Wu L
AD  - Asociados de Macula, Vitreo y Retina de Costa Rica, San Jose, Costa Rica.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170129
PL  - United States
TA  - Asia Pac J Ophthalmol (Phila)
JT  - Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)
JID - 101583622
SB  - IM
MH  - Diabetic Retinopathy/*diagnostic imaging
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Fluorescein Angiography/methods
MH  - Humans
MH  - Macular Edema/*diagnostic imaging
MH  - Multimodal Imaging/*methods
MH  - Ophthalmoscopy/methods
MH  - Optical Imaging/*methods
MH  - Optics and Photonics/methods
MH  - Tomography, Optical Coherence/methods
OTO - NOTNLM
OT  - OCT
OT  - OCT angiography
OT  - adaptive optics
OT  - confocal scanning laser ophthalmoscope
OT  - diabetic macular edema
OT  - diabetic retinopathy
OT  - fluorescein angiography
OT  - fluorescence lifetime imaging ophthalmoscopy
OT  - fundus autofluorescence
OT  - fundus imaging
OT  - macular pigment optical density
OT  - ultra-widefield fluorescein angiography
EDAT- 2018/01/30 06:00
MHDA- 2018/03/21 06:00
CRDT- 2018/01/30 06:00
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2018/01/30 06:00 [entrez]
AID - S2162-0989(23)00436-X [pii]
AID - 10.22608/APO.2017504 [doi]
PST - ppublish
SO  - Asia Pac J Ophthalmol (Phila). 2018 Jan-Feb;7(1):22-27. doi: 
      10.22608/APO.2017504. Epub 2017 Jan 29.