PMID- 29377065 OWN - NLM STAT- MEDLINE DCOM- 20190712 LR - 20190712 IS - 1399-6576 (Electronic) IS - 0001-5172 (Linking) VI - 62 IP - 5 DP - 2018 May TI - The effects of added whey protein to a pre-operative carbohydrate drink on glucose and insulin response. PG - 620-627 LID - 10.1111/aas.13069 [doi] AB - BACKGROUND: Pre-operative complex carbohydrate (CHO) drinks are recommended to attenuate post-operative insulin resistance. However, many institutions use simple CHO drinks, which while convenient, may have less metabolic effects. Whey protein may enhance insulin release when added to complex CHO. The aim of this study was to compare the insulin response to simple CHO vs. simple CHO supplemented with whey protein. METHODS: Twelve healthy volunteers participated in this double-blinded, within subject, cross-over design study investigating insulin response to simple CHO drink vs. simple CHO + whey (CHO + W) drink. The primary outcome was the accumulated insulin response during 180 min after ingestion of the drinks (Area under the curve, AUC). Secondary outcomes included plasma glucose and ghrelin levels, and gastric emptying rate estimated by acetaminophen absorption technique. Data presented as mean (SD). RESULTS: There was no differences in accumulated insulin response after the CHO or CHO + W drinks [AUC: 15 (8) vs. 20 (14) nmol/l, P = 0.27]. Insulin and glucose levels peaked between 30 and 60 min and reached 215 (95) pmol/l and 7 (1) mmol/l after the CHO drink and to 264 (232) pmol/l and 6.5 (1) mmol/l after the CHO + W drink. There were no differences in glucose or ghrelin levels or gastric emptying with the addition of whey. CONCLUSION: The addition of whey protein to a simple CHO drink did not change the insulin response in healthy individuals. The peak insulin responses to simple CHO with or without whey protein were lower than that previously reported with complex CHO drinks. The impact of simple carbohydrate drinks with lower insulin response on peri-operative insulin sensitivity requires further study. CI - (c) 2018 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. FAU - Karimian, N AU - Karimian N AUID- ORCID: 0000-0002-3700-8124 AD - Experimental Surgery, McGill University, Montreal, QC, Canada. FAU - Moustafa, M AU - Moustafa M AD - Department of Anesthesia, McGill University, Montreal, QC, Canada. FAU - Mata, J AU - Mata J AD - Department of Surgery, McGill University, Montreal, QC, Canada. FAU - Al-Saffar, A K AU - Al-Saffar AK AD - Department of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden. FAU - Hellstrom, P M AU - Hellstrom PM AD - Department of Medical Sciences, Gastroenterology and Hepatology Unit, Uppsala University, Uppsala, Sweden. FAU - Feldman, L S AU - Feldman LS AD - Department of Surgery, McGill University, Montreal, QC, Canada. FAU - Carli, F AU - Carli F AD - Department of Anesthesia, McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20180128 PL - England TA - Acta Anaesthesiol Scand JT - Acta anaesthesiologica Scandinavica JID - 0370270 RN - 0 (Blood Glucose) RN - 0 (Dietary Carbohydrates) RN - 0 (Ghrelin) RN - 0 (Insulin) RN - 0 (Whey Proteins) SB - IM MH - Adult MH - Aged MH - Blood Glucose/*analysis MH - Cross-Over Studies MH - Dietary Carbohydrates/*administration & dosage MH - Double-Blind Method MH - Gastric Emptying MH - Ghrelin/blood MH - Humans MH - Insulin/*blood MH - Middle Aged MH - Whey Proteins/*administration & dosage EDAT- 2018/01/30 06:00 MHDA- 2019/07/13 06:00 CRDT- 2018/01/30 06:00 PHST- 2017/08/16 00:00 [received] PHST- 2017/11/29 00:00 [revised] PHST- 2017/12/12 00:00 [accepted] PHST- 2018/01/30 06:00 [pubmed] PHST- 2019/07/13 06:00 [medline] PHST- 2018/01/30 06:00 [entrez] AID - 10.1111/aas.13069 [doi] PST - ppublish SO - Acta Anaesthesiol Scand. 2018 May;62(5):620-627. doi: 10.1111/aas.13069. Epub 2018 Jan 28.