PMID- 29377365
OWN - NLM
STAT- MEDLINE
DCOM- 20191014
LR  - 20191014
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 30
IP  - 7
DP  - 2018 Jul
TI  - Neonatal exposure to oestradiol increases dopaminergic transmission in nucleus 
      accumbens and morphine-induced conditioned place preference in adult female rats.
PG  - e12574
LID - 10.1111/jne.12574 [doi]
AB  - Steroid sex hormones produce physiological effects in reproductive tissues and 
      also in nonreproductive tissues, such as the brain, particularly in cortical, 
      limbic and midbrain areas. Dopamine (DA) neurones involved in processes such as 
      prolactin secretion (tuberoinfundibular system), motor circuit regulation 
      (nigrostriatal system) and driving of motivated behaviour (mesocorticolimbic 
      system) are specially regulated by sex hormones. Indeed, sex hormones promote 
      neurochemical and behavioural effects induced by drugs of abuse by tuning 
      midbrain DA neurones in adult animals. However, the long-term effects induced by 
      neonatal exposure to sex hormones on dopaminergic neurotransmission have not been 
      fully studied. The present study aimed to determine whether a single neonatal 
      exposure with oestradiol valerate (EV) results in a programming of dopaminergic 
      neurotransmission in the nucleus accumbens (NAcc) of adult female rats. To answer 
      this question, electrophysiological, neurochemical, cellular, molecular and 
      behavioural techniques were used. The data show that frequency but not amplitude 
      of the spontaneous excitatory postsynaptic current is significantly increased in 
      NAcc medium spiny neurones of EV-treated rats. In addition, DA content and 
      release are both increased in the NAcc of EV-treated rats, caused by an increased 
      synthesis of this neurotransmitter. These results are functionally associated 
      with a higher percentage of EV-treated rats conditioned to morphine, a drug of 
      abuse, compared to controls. In conclusion, neonatal programming with oestradiol 
      increases NAcc dopaminergic neurotransmission in adulthood, which may be 
      associated with increased reinforcing effects of drugs of abuse.
CI  - (c) 2018 British Society for Neuroendocrinology.
FAU - Bonansco, C
AU  - Bonansco C
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Martinez-Pinto, J
AU  - Martinez-Pinto J
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Silva, R A
AU  - Silva RA
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Velasquez, V B
AU  - Velasquez VB
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Martorell, A
AU  - Martorell A
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
AD  - Escuela de Fonoaudiologia, Facultad de Ciencias de la Rehabilitacion, Universidad 
      Andres Bello, Vina del Mar, Chile.
FAU - Selva, M V
AU  - Selva MV
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Espinosa, P
AU  - Espinosa P
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Moya, P R
AU  - Moya PR
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
AD  - Nucleo Milenio Biologia de Enfermedades Neuropsiquiatricas (NUMIND), Valparaiso, 
      Chile.
AD  - Centro Interdisciplinario de Neurociencia de Valparaiso, Valparaiso, Chile.
FAU - Cruz, G
AU  - Cruz G
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
FAU - Andres, M E
AU  - Andres ME
AD  - Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, 
      Pontificia Universidad Catolica de Chile, Santiago, Chile.
FAU - Sotomayor-Zarate, R
AU  - Sotomayor-Zarate R
AUID- ORCID: 0000-0002-1239-5367
AD  - Centro de Neurobiologia y Plasticidad Cerebral, Instituto de Fisiologia, Facultad 
      de Ciencias, Universidad de Valparaiso, Valparaiso, Chile.
LA  - eng
SI  - GENBANK/NM_012740
SI  - GENBANK/NR_046237
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Estrogens)
RN  - 4TI98Z838E (Estradiol)
RN  - 76I7G6D29C (Morphine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Analgesics, Opioid/pharmacology
MH  - Animals
MH  - Conditioning, Operant/*drug effects
MH  - Dopamine/*metabolism
MH  - Dopaminergic Neurons/drug effects/metabolism
MH  - Estradiol/*pharmacology
MH  - Estrogens/pharmacology
MH  - Female
MH  - Morphine/*pharmacology
MH  - Neurons/*drug effects/metabolism
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Synaptic Transmission/*drug effects
OTO - NOTNLM
OT  - dopamine
OT  - microdialysis
OT  - morphine
OT  - oestradiol
OT  - programming
EDAT- 2018/01/30 06:00
MHDA- 2019/10/15 06:00
CRDT- 2018/01/30 06:00
PHST- 2017/07/19 00:00 [received]
PHST- 2018/01/16 00:00 [revised]
PHST- 2018/01/19 00:00 [accepted]
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2019/10/15 06:00 [medline]
PHST- 2018/01/30 06:00 [entrez]
AID - 10.1111/jne.12574 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2018 Jul;30(7):e12574. doi: 10.1111/jne.12574.