PMID- 29377939
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Plasma concentration of selected biochemical markers of endothelial dysfunction 
      in women with various severity of chronic venous insufficiency (CVI)-A pilot 
      study.
PG  - e0191902
LID - 10.1371/journal.pone.0191902 [doi]
LID - e0191902
AB  - BACKGROUND: Although the endothelial dysfunction is considered to be implicated 
      in the pathogenesis of chronic venous insufficiency (CVI) the endothelial status 
      in patients with venous disorders is still not fully evaluated. Therefore the aim 
      of the study was to measure the concentration of selected markers of endothelial 
      dysfunction: von Willebrand factor (vWf), soluble P-selectin (sP-selectin), 
      soluble thrombomodulin (sTM) and soluble VE-cadherin (sVE-cadherin) in CVI women 
      who constitute the most numerous group of patients suffering from venous disease. 
      MATERIALS AND METHODS: Forty four women with CVI were involved in the study and 
      divided into subgroups based on CEAP classification. Concentration of vWf, 
      sP-selectin, sTM and sVE-cadherin were measured and compared with those obtained 
      in 25 healthy age and sex-matched women. RESULTS: It was found that the 
      concentration of sTM increased and sVEcadherin decreased along with disease 
      severity in CVI women. A significant rise of sTM was observed especially in CVI 
      women, with the highest inflammation status reflected by hsCRP or elastase 
      concentration, and in CVI women with a high oxidative stress manifested by an 
      increased plasma MDA. A significant fall of circulating sVE-cadherin was reported 
      in CVI women with moderate to highest intensity of inflammation and oxidative 
      stress. There was no change in vWF and sP-selectin concentration at any stage of 
      CVI severity. CONCLUSIONS: The results of the present study demonstrate the 
      presence of endothelial dysfunction in women suffering from CVI which seems to 
      progress with the disease severity and may be associated with inflammation and 
      enhanced oxidative stress.
FAU - Budzyn, Magdalena
AU  - Budzyn M
AD  - Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, 
      Poznan University of Medical Sciences, Poznan, Poland.
FAU - Iskra, Maria
AU  - Iskra M
AD  - Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, 
      Poznan University of Medical Sciences, Poznan, Poland.
FAU - Turkiewicz, Wojciech
AU  - Turkiewicz W
AD  - Department of General Surgery, Medical Center HCP, Poznan, Poland.
FAU - Krasinski, Zbigniew
AU  - Krasinski Z
AD  - Department of General and Vascular Surgery, Poznan University of Medical 
      Sciences, Poznan, Poland.
FAU - Gryszczynska, Bogna
AU  - Gryszczynska B
AD  - Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, 
      Poznan University of Medical Sciences, Poznan, Poland.
FAU - Kasprzak, Magdalena Paulina
AU  - Kasprzak MP
AD  - Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, 
      Poznan University of Medical Sciences, Poznan, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180129
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antigens, CD)
RN  - 0 (Biomarkers)
RN  - 0 (Cadherins)
RN  - 0 (P-Selectin)
RN  - 0 (Thrombomodulin)
RN  - 0 (cadherin 5)
RN  - 0 (von Willebrand Factor)
SB  - IM
MH  - Adult
MH  - Antigens, CD/blood
MH  - Biomarkers/*blood
MH  - Cadherins/blood
MH  - Chronic Disease
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - P-Selectin/blood
MH  - Pilot Projects
MH  - Severity of Illness Index
MH  - Thrombomodulin/blood
MH  - Venous Insufficiency/*blood
MH  - von Willebrand Factor/metabolism
PMC - PMC5788369
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/01/30 06:00
MHDA- 2018/03/10 06:00
PMCR- 2018/01/29
CRDT- 2018/01/30 06:00
PHST- 2017/09/14 00:00 [received]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/01/30 06:00 [entrez]
PHST- 2018/01/30 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2018/01/29 00:00 [pmc-release]
AID - PONE-D-17-33484 [pii]
AID - 10.1371/journal.pone.0191902 [doi]
PST - epublish
SO  - PLoS One. 2018 Jan 29;13(1):e0191902. doi: 10.1371/journal.pone.0191902. 
      eCollection 2018.