PMID- 29379194
OWN - NLM
STAT- MEDLINE
DCOM- 20181226
LR  - 20190401
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Print)
IS  - 1018-4813 (Linking)
VI  - 26
IP  - 4
DP  - 2018 Apr
TI  - Psychosocial impact on mothers receiving expanded newborn screening results.
PG  - 477-484
LID - 10.1038/s41431-017-0069-z [doi]
AB  - Expanded newborn screening (NBS) for genetic disorders has improved diagnosis of 
      numerous treatable diseases, positively impacting children's health outcomes. 
      However, research about the psychological impact of expanded NBS on families, 
      especially mothers, has been mixed. Our study examined associations between 
      maternal experiences of expanded NBS and subsequent psychosocial functioning and 
      parenting stress in mothers whose infants received either true negative (TN), 
      true positive (TP) or false positive (FP) results after a 4- to 6-month period. 
      The Parenting Stress Index and the Depression, Anxiety and Stress Scale were used 
      to assess symptoms of anxiety, stress and depression in 3 sets of mothers, whose 
      infants received TN (n = 31), TP (n = 8) or FP (n = 18) results. Multivariate 
      analyses of variance (MANOVA) results revealed no significant differences among 
      these three groups of mothers regarding overall anxiety, stress and depression. 
      However, FP mothers experienced lower levels of stress related to their own 
      health compared to TN group. Two potential trends were also identified; results 
      suggested TN mothers might experience higher levels of isolation than mothers in 
      the TP group and that FP mothers might report higher stress levels in relation to 
      spousal relationships compared to the TN group. FP mothers seemed to report 
      similar or better levels of psychosocial functioning than TN mothers. Our 
      findings are encouraging with respect to impacts of NBS on maternal well-being. 
      We also identify key areas for improvement (parental education) and research 
      (isolation and spousal relationships).
FAU - O'Connor, Kathleen
AU  - O'Connor K
AD  - Department of Psychology, Western University, London, ON, Canada.
FAU - Jukes, Tara
AU  - Jukes T
AD  - Department of Psychology, Western University, London, ON, Canada.
FAU - Goobie, Sharan
AU  - Goobie S
AD  - Department of Pediatrics, Western University, London, ON, Canada.
FAU - DiRaimo, Jennifer
AU  - DiRaimo J
AD  - Department of Pediatrics, Western University, London, ON, Canada.
FAU - Moran, Greg
AU  - Moran G
AD  - Department of Psychology, Western University, London, ON, Canada.
FAU - Potter, Beth Katherine
AU  - Potter BK
AD  - School of Epidemiology, Public Health and Preventative Medicine, University of 
      Ottawa, Ottawa, ON, Canada.
FAU - Chakraborty, Pranesh
AU  - Chakraborty P
AD  - Newborn Screening, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada.
FAU - Rupar, Charles Anthony
AU  - Rupar CA
AD  - Department of Pediatrics, Western University, London, ON, Canada.
AD  - Children's Health Research Institute Ontario, London, ON, Canada.
AD  - Department of Pathology and Laboratory Medicine, Western University, London, ON, 
      Canada.
FAU - Gannavarapu, Srinitya
AU  - Gannavarapu S
AD  - Department of Pediatrics, Western University, London, ON, Canada.
FAU - Prasad, Chitra
AU  - Prasad C
AD  - Department of Pediatrics, Western University, London, ON, Canada. 
      chitra.prasad@lhsc.on.ca.
AD  - Children's Health Research Institute Ontario, London, ON, Canada. 
      chitra.prasad@lhsc.on.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180129
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Counseling/psychology
MH  - Genetic Testing
MH  - Humans
MH  - Infant, Newborn
MH  - Metabolism, Inborn Errors/diagnosis/*psychology
MH  - Mothers/*psychology
MH  - Neonatal Screening/*psychology
MH  - Stress, Psychological/*epidemiology/psychology
PMC - PMC5891497
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/01/31 06:00
MHDA- 2018/12/27 06:00
PMCR- 2019/04/01
CRDT- 2018/01/31 06:00
PHST- 2017/04/14 00:00 [received]
PHST- 2017/11/18 00:00 [accepted]
PHST- 2017/10/20 00:00 [revised]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/12/27 06:00 [medline]
PHST- 2018/01/31 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 10.1038/s41431-017-0069-z [pii]
AID - 69 [pii]
AID - 10.1038/s41431-017-0069-z [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2018 Apr;26(4):477-484. doi: 10.1038/s41431-017-0069-z. Epub 
      2018 Jan 29.