PMID- 29379353
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 25
IP  - 1
DP  - 2018 Jan
TI  - Assessment of gender-related differences in vitamin D levels and cardiovascular 
      risk factors in Saudi patients with type 2 diabetes mellitus.
PG  - 31-36
LID - 10.1016/j.sjbs.2017.04.001 [doi]
AB  - Diabetes is a major risk factor for cardiovascular disease (CVD) including 
      stroke, coronary heart disease, and peripheral artery disease. It remains a 
      leading cause of mortality throughout the world, affecting both women and men. 
      This investigation was aimed to study gender based differences in cardiovascular 
      risk factors of adult population with type-2 diabetes mellitus (T2DM) and to 
      check the correlation between serum HbA1C, lipid profile and serum vitamin D 
      levels, in T2DM patients of Riyadh, Saudi Arabia. This hospital-based 
      cross-sectional study involving subjects was divided into two gender based 
      groups; normal male (800), diabetic male (800) and normal female (800) and T2DM 
      females (800). Blood samples were analyzed for fasting glucose (FBG), HbA1c, 
      total cholesterol (TC), triglycerides (Tg), low density lipoprotein cholesterol 
      (LDL-C), high density lipoprotein cholesterol (HDL-C) and serum levels of 
      25(OH)-vitamin D in all groups. All the glycemic control parameters and lipid 
      profile parameters were found to be significantly different in diabetic vs 
      non-diabetic group (p < 0.001) in both genders. The results also show that 
      vitamin D concentration decreased significantly (p < 0.001) in diabetic patients 
      than the healthy individuals in both the genders. Vitamin-D and HbA1C were 
      negatively correlated in both males and females in T2DM patients and significant 
      at P < 0.05. Our study reveals that dyslipidemia remains one of the major risk 
      factors of CVD in T2DM. In addition to dyslipidemia, decreased levels of 
      vitamin-D associated with increased HbA1C alarms the early diagnosis of Type 2 
      Diabetes.
FAU - Abudawood, Manal
AU  - Abudawood M
AD  - Department of Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Tabassum, Hajera
AU  - Tabassum H
AD  - Department of Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Ansar, Sabah
AU  - Ansar S
AD  - Department of Clinical Laboratory Sciences, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Almosa, Khalid
AU  - Almosa K
AD  - Center for Health Studies, Prince Sultan Military Medical City, Riyadh, Saudi 
      Arabia.
FAU - Sobki, Samia
AU  - Sobki S
AD  - Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, 
      Riyadh, Saudi Arabia.
FAU - Ali, Mir Naiman
AU  - Ali MN
AD  - Department of Microbiology, Mumtaz Degree & P.G. College, Hyderabad, India.
FAU - Aljohi, Ali
AU  - Aljohi A
AD  - Central Military Laboratory & Blood Bank, Prince Sultan Military Medical City, 
      Riyadh, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20170404
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC5775082
OTO - NOTNLM
OT  - HbA1c
OT  - Lipoproteins
OT  - Type 2 diabetes mellitus
OT  - Vitamin-D
EDAT- 2018/01/31 06:00
MHDA- 2018/01/31 06:01
PMCR- 2017/04/04
CRDT- 2018/01/31 06:00
PHST- 2017/01/15 00:00 [received]
PHST- 2017/03/14 00:00 [revised]
PHST- 2017/04/02 00:00 [accepted]
PHST- 2018/01/31 06:00 [entrez]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/01/31 06:01 [medline]
PHST- 2017/04/04 00:00 [pmc-release]
AID - S1319-562X(17)30115-8 [pii]
AID - 10.1016/j.sjbs.2017.04.001 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2018 Jan;25(1):31-36. doi: 10.1016/j.sjbs.2017.04.001. Epub 
      2017 Apr 4.