PMID- 29379495
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200115
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 8
DP  - 2017
TI  - AIMp1 Potentiates T(H)1 Polarization and Is Critical for Effective Antitumor and 
      Antiviral Immunity.
PG  - 1801
LID - 10.3389/fimmu.2017.01801 [doi]
LID - 1801
AB  - Dendritic cells (DCs) must integrate a broad array of environmental cues to exact 
      control over downstream immune responses including T(H) polarization. The 
      multienzyme aminoacyl-tRNA synthetase complex component AIMp1/p43 responds to 
      cellular stress and exerts pro-inflammatory functions; however, a role for 
      DC-expressed AIMp1 in T(H) polarization has not previously been shown. Here, we 
      demonstrate that the absence of AIMp1 in bone marrow-derived DC (BMDC) 
      significantly impairs cytokine and costimulatory molecule expression, p38 MAPK 
      signaling, and T(H)1 polarization of cocultured T-cells while significantly 
      dysregulating immune-related gene expression. These deficits resulted in 
      significantly compromised BMDC vaccine-mediated protection against melanoma. 
      AIMp1 within the host was also critical for innate and adaptive antiviral 
      immunity against influenza virus infection in vivo. Cancer patients with AIMp1 
      expression levels in the highest tertiles exhibited a 70% survival advantage at 
      15-year postdiagnosis as determined by bioinformatics analysis of nearly 9,000 
      primary human tumor samples in The Cancer Genome Atlas database. These data 
      establish the importance of AIMp1 for the effective governance of antitumor and 
      antiviral immune responses.
FAU - Liang, Dan
AU  - Liang D
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Tian, Lin
AU  - Tian L
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX, United States.
FAU - You, Ran
AU  - You R
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Halpert, Matthew M
AU  - Halpert MM
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Konduri, Vanaja
AU  - Konduri V
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Baig, Yunyu C
AU  - Baig YC
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Paust, Silke
AU  - Paust S
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
AD  - Department of Pediatrics, Texas Children's Hospital, Houston, TX, United States.
AD  - Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, United 
      States.
AD  - Department of Molecular Virology and Microbiology, Baylor College of Medicine, 
      Houston, TX, United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
FAU - Kim, Doyeun
AU  - Kim D
AD  - Medicinal Bioconvergence Research Center, Department of Molecular Medicine and 
      Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea.
FAU - Kim, Sunghoon
AU  - Kim S
AD  - Medicinal Bioconvergence Research Center, Department of Molecular Medicine and 
      Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea.
FAU - Jia, Fuli
AU  - Jia F
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX, United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Antibody-based Proteomics Core, Baylor College of Medicine, Houston, TX, United 
      States.
FAU - Huang, Shixia
AU  - Huang S
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX, United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Antibody-based Proteomics Core, Baylor College of Medicine, Houston, TX, United 
      States.
FAU - Zhang, Xiang
AU  - Zhang X
AD  - Department of Molecular and Cellular Biology, Baylor College of Medicine, 
      Houston, TX, United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, 
      United States.
FAU - Kheradmand, Farrah
AU  - Kheradmand F
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
AD  - Division of Pulmonary, Critical Care, and Sleep Medicine, Baylor College of 
      Medicine, Houston, TX, United States.
FAU - Corry, David B
AU  - Corry DB
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
AD  - Division of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, 
      Houston, TX, United States.
FAU - Gilbert, Brian E
AU  - Gilbert BE
AD  - Department of Molecular Virology and Microbiology, Baylor College of Medicine, 
      Houston, TX, United States.
FAU - Levitt, Jonathan M
AU  - Levitt JM
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Scott Department of Urology, Baylor College of Medicine, Houston, TX, United 
      States.
FAU - Decker, William K
AU  - Decker WK
AD  - Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 
      United States.
AD  - Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, United 
      States.
AD  - Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, United 
      States.
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - R01 AI127387/AI/NIAID NIH HHS/United States
GR  - P30 CA125123/CA/NCI NIH HHS/United States
GR  - P30 AI036211/AI/NIAID NIH HHS/United States
GR  - S10 RR024574/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20180115
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC5775236
OTO - NOTNLM
OT  - AIMp1
OT  - IL-12
OT  - TH1 immunity
OT  - antitumor immunity
OT  - antiviral immunity
OT  - dendritic cell
OT  - p38 MAPK signaling
EDAT- 2018/01/31 06:00
MHDA- 2018/01/31 06:01
PMCR- 2017/01/01
CRDT- 2018/01/31 06:00
PHST- 2017/10/06 00:00 [received]
PHST- 2017/11/30 00:00 [accepted]
PHST- 2018/01/31 06:00 [entrez]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/01/31 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2017.01801 [doi]
PST - epublish
SO  - Front Immunol. 2018 Jan 15;8:1801. doi: 10.3389/fimmu.2017.01801. eCollection 
      2017.