PMID- 29381285
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20190923
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 13
IP  - 3
DP  - 2017 Mar
TI  - Development of Dynamic Liquid and Conjugated Electrospun 
      Poly(L-lactide-co-caprolactone)/Collagen Nanoyarns for Regulating Vascular Smooth 
      Muscle Cells Growth.
PG  - 303-12
AB  - Simulating the modeling of smooth muscle layer in the vascular structure makes a 
      great difference for vascular tissue regeneration. A functional tissue engineered 
      vascular media shall promote the aligned organization and three-dimensional 
      penetration of smooth muscle cells (SMCs) into the scaffold. To this aim, dynamic 
      liquid and conjugated nanoyarns based on poly(L-lactide-co-caprolactone) 
      (P(LLA-CL)) and collagen (COL) with a weight ratio at 3:1 were fabricated by 
      electrospinning methods, with random and aligned nanofibers as control groups. 
      The Fourier transform infrared spectroscopy and X-ray diffraction analyses 
      confirmed the preservation of P(LLA-CL)/COL components and structure. Scanning 
      electron microscope (SEM) results indicated a significant increase of yarn 
      diameters at 19.27 +/- 6.16 mum (dynamic liquid) and 10.24 +/- 3.09 mum (conjugated), 
      and both of the nanoyarns had improved mechanical tensile properties than the 
      random nanofibers. Compared with random and aligned nanofibers, the nanoyarns 
      presented significant higher porosity and larger pore diameter, leading to a 
      decrease of water contact angle and a promotion of SMCs proliferation and 
      migration. Better SMCs orientation was observed on the conjugated nanoyarns, 
      while superior SMCs penetration was achieved on the dynamic liquid nanoyarns, 
      owing to the differences in yarns microstructure. Herein, this study demonstrated 
      that the aligned and porous P(LLA-CL)/COL nanoyarns fabricated by dynamic liquid 
      and conjugated electrospinning were beneficial to regulating vascular SMCs 
      outgrowth, which had important implications for functional reconstruction of 
      vascular media.
FAU - Wu, Tong
AU  - Wu T
FAU - Zhang, Jialing
AU  - Zhang J
FAU - Wang, Yuanfei
AU  - Wang Y
FAU - Sun, Binbin
AU  - Sun B
FAU - Guo, Xuran
AU  - Guo X
FAU - Morsi, Yosry
AU  - Morsi Y
FAU - El-Hamshary, Hany
AU  - El-Hamshary H
FAU - El-Newehy, Mohamed
AU  - El-Newehy M
FAU - Mo, Xiumei
AU  - Mo X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
RN  - 0 (Biocompatible Materials)
RN  - 0 (Nanoconjugates)
RN  - 0 (Polyesters)
RN  - 0 (poly(lactic acid-co-epsilon-caprolactone))
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Biocompatible Materials/*chemical synthesis
MH  - Cell Proliferation/physiology
MH  - Cells, Cultured
MH  - Collagen/*chemistry
MH  - Electroplating/methods
MH  - Equipment Design
MH  - Equipment Failure Analysis
MH  - Humans
MH  - Muscle, Smooth, Vascular/*cytology/physiology
MH  - Myocytes, Smooth Muscle/*cytology/physiology
MH  - Nanoconjugates/*chemistry/ultrastructure
MH  - Polyesters/*chemistry
MH  - Rotation
MH  - *Tissue Scaffolds
OTO - NOTNLM
OT  - *Electrospinning
OT  - *Nanoyarns
OT  - *P(LLA-CL)
OT  - *Collagen
OT  - *Smooth Muscle Cells
EDAT- 2018/01/31 06:00
MHDA- 2018/02/24 06:00
CRDT- 2018/01/31 06:00
PHST- 2018/01/31 06:00 [entrez]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - 10.1166/jbn.2017.2352 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2017 Mar;13(3):303-12. doi: 10.1166/jbn.2017.2352.