PMID- 29381475
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20240318
IS  - 2191-0308 (Electronic)
IS  - 0048-7554 (Print)
IS  - 0048-7554 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Mar 28
TI  - The role of nutrition in influencing mechanisms involved in environmentally 
      mediated diseases.
PG  - 87-97
LID - 10.1515/reveh-2017-0038 [doi]
AB  - Human exposure to environmental contaminants such as persistent chlorinated 
      organics, heavy metals, pesticides, phthalates, flame retardants, electronic 
      waste and airborne pollutants around the world, and especially in Southeast Asian 
      regions, are significant and require urgent attention. Given this widespread 
      contamination and abundance of such toxins as persistent organic pollutants 
      (POPs) in the ecosystem, it is unlikely that remediation alone will be sufficient 
      to address the health impacts associated with this exposure. Furthermore, we must 
      assume that the impact on health of some of these contaminants results in 
      populations with extraordinary vulnerabilities to disease risks. Further 
      exacerbating risk; infectious diseases, poverty and malnutrition are common in 
      the Southeast Asian regions of the world. Thus, exploring preventive measures of 
      environmental exposure and disease risk through new paradigms of environmental 
      toxicology, optimal and/or healthful nutrition and health is essential. For 
      example, folic acid supplementation can lower blood arsenic levels, and 
      plant-derived bioactive nutrients can lower cardiovascular and cancer risks 
      linked to pollutant exposure. Data also indicate that diets enriched with 
      bioactive food components such as polyphenols and omega-3 polyunsaturated fatty 
      acids can prevent or decrease toxicant-induced inflammation. Thus, consuming 
      healthy diets that exhibit high levels of antioxidant and anti-inflammatory 
      properties, is a meaningful way to reduce the vulnerability to non-communicable 
      diseases linked to environmental toxic insults. This nutritional paradigm in 
      environmental toxicology requires further study in order to improve our 
      understanding of the relationship between nutrition or other lifestyle 
      modifications and toxicant-induced diseases. Understanding mechanistic 
      relationships between nutritional modulation of environmental toxicants and 
      susceptibility to disease development are important for both cumulative risk 
      assessment and the design and implementation of future public health programs and 
      behavioral interventions.
FAU - Hennig, Bernhard
AU  - Hennig B
AD  - University of Kentucky Superfund Research Center, University of Kentucky, 
      Lexington, KY 40536, USA.
FAU - Petriello, Michael C
AU  - Petriello MC
AD  - University of Kentucky Superfund Research Center, University of Kentucky, 
      Lexington, KY 40536, USA.
FAU - Gamble, Mary V
AU  - Gamble MV
AD  - Department of Environmental Health Sciences, Mailman School of Public Health, 
      Columbia University, NY, USA.
FAU - Surh, Young-Joon
AU  - Surh YJ
AD  - Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul 
      National University, Seoul 151-742 08826, South Korea.
FAU - Kresty, Laura A
AU  - Kresty LA
AD  - Section of Thoracic Surgery, Department of Surgery, University of Michigan, Ann 
      Arbor, MI, 48109, MI, USA.
FAU - Frank, Norbert
AU  - Frank N
AD  - German Cancer Research Center, 69120 Heidelberg, Germany.
FAU - Rangkadilok, Nuchanart
AU  - Rangkadilok N
AD  - Chulabhorn Research Institute, Bangkok 10210, Thailand.
FAU - Ruchirawat, Mathuros
AU  - Ruchirawat M
AD  - Chulabhorn Research Institute, Bangkok 10210, Thailand.
FAU - Suk, William A
AU  - Suk WA
AD  - National Institute of Environmental Health Sciences, National Institutes of 
      Health, Research Triangle Park, NC, USA.
LA  - eng
GR  - P30 ES009089/ES/NIEHS NIH HHS/United States
GR  - R01 CA158319/CA/NCI NIH HHS/United States
GR  - R13 ES027338/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Environ Health
JT  - Reviews on environmental health
JID - 0425754
SB  - IM
MH  - *Environmental Exposure
MH  - Humans
MH  - Noncommunicable Diseases/*epidemiology/*prevention & control
MH  - *Nutritional Status
PMC - PMC5987536
MID - NIHMS971415
OTO - NOTNLM
OT  - bioactive foods
OT  - environmental pollutants
OT  - inflammatory diseases
EDAT- 2018/01/31 06:00
MHDA- 2018/08/17 06:00
PMCR- 2018/06/05
CRDT- 2018/01/31 06:00
PHST- 2017/10/11 00:00 [received]
PHST- 2017/12/13 00:00 [accepted]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2018/01/31 06:00 [entrez]
PHST- 2018/06/05 00:00 [pmc-release]
AID - reveh-2017-0038 [pii]
AID - 10.1515/reveh-2017-0038 [doi]
PST - ppublish
SO  - Rev Environ Health. 2018 Mar 28;33(1):87-97. doi: 10.1515/reveh-2017-0038.