PMID- 29381773
OWN - NLM
STAT- MEDLINE
DCOM- 20180309
LR  - 20191210
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 13
IP  - 1
DP  - 2018
TI  - Association of circulating CTRP9 with soluble adhesion molecules and inflammatory 
      markers in patients with type 2 diabetes mellitus and coronary artery disease.
PG  - e0192159
LID - 10.1371/journal.pone.0192159 [doi]
LID - e0192159
AB  - C1q/TNF-related protein 9 (CTRP9) is a paralogue of adiponectin with known 
      favorable effects on lipid and glucose metabolism. A potential role of CTRP9 for 
      regulation of endothelium function has been suggested by previous studies. 
      However, no studies have examined the relation between serum CTRP9 levels and 
      adhesion molecules in patients with type 2 diabetes mellitus (T2DM) and coronary 
      artery disease (CAD). The present study was conducted on 337 subjects who 
      underwent coronary angiography and were categorized into four groups according to 
      the presence of CAD and T2DM (control, CAD, T2DM and CAD+T2DM). Serum levels of 
      CTRP9, adiponectin, sICAM-1, sVCAM-1, sE-Selectin, IL-6 and TNF-alpha were measured. 
      It was found that the circulating CTRP9 levels were independently associated with 
      increased risk of CAD and T2DM in addition to elevated levels of serum CTRP9 in 
      CAD, T2DM and CAD+T2DM groups. A significant association of serum CTRP9 levels 
      with adhesion molecules in CAD and T2DM patients as well as serum TNF-alpha levels in 
      CAD individuals was noted. A significant relation between the circulating levels 
      of CTRP9 and HOMA-IR in T2DM subjects was also observed. The results revealed 
      increased circulating levels of CTRP9 in T2DM and CAD individuals which suggests 
      a compensatory response to insulin resistance, inflammatory milieu and 
      endothelial dysfunction; however, more studies are needed to confirm this.
FAU - Moradi, Nariman
AU  - Moradi N
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran.
FAU - Fadaei, Reza
AU  - Fadaei R
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Kermanshah University 
      of Medical Sciences, Kermanshah, Iran.
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Emamgholipour, Solaleh
AU  - Emamgholipour S
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Kazemian, Elham
AU  - Kazemian E
AD  - Department of Basic Sciences and Cellular and Molecular Nutrition, Faculty of 
      Nutrition Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Panahi, Ghodratollah
AU  - Panahi G
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Vahedi, Siamak
AU  - Vahedi S
AD  - Department of Cardiology, Faculty of medicine. Kurdistan University of Medical 
      Science, Sanandaj, Iran.
FAU - Saed, Lotfolah
AU  - Saed L
AD  - Department of Internal Medicine, Faculty of Medicine, Kurdistan University of 
      Medical Sciences, Sanandaj, Iran.
FAU - Fallah, Soudabeh
AU  - Fallah S
AUID- ORCID: 0000-0002-7377-6577
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Iran University of 
      Medical Sciences, Tehran, Iran.
AD  - Research center of Pediatric Infectious Disease, Rasool Akram Hospital, Iran 
      University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180130
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (C1QTNF9B protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Glycoproteins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)
SB  - IM
MH  - Adiponectin/*blood
MH  - Biomarkers/*blood
MH  - Cell Adhesion Molecules/*blood
MH  - Coronary Artery Disease/*blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Glycoproteins/*blood
MH  - Humans
MH  - Inflammation Mediators/*blood
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
PMC - PMC5790264
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2018/01/31 06:00
MHDA- 2018/03/10 06:00
PMCR- 2018/01/30
CRDT- 2018/01/31 06:00
PHST- 2017/10/29 00:00 [received]
PHST- 2018/01/17 00:00 [accepted]
PHST- 2018/01/31 06:00 [entrez]
PHST- 2018/01/31 06:00 [pubmed]
PHST- 2018/03/10 06:00 [medline]
PHST- 2018/01/30 00:00 [pmc-release]
AID - PONE-D-17-38499 [pii]
AID - 10.1371/journal.pone.0192159 [doi]
PST - epublish
SO  - PLoS One. 2018 Jan 30;13(1):e0192159. doi: 10.1371/journal.pone.0192159. 
      eCollection 2018.