PMID- 29382967
OWN - NLM
STAT- MEDLINE
DCOM- 20180813
LR  - 20181113
IS  - 1928-9022 (Electronic)
IS  - 0830-9000 (Print)
IS  - 0830-9000 (Linking)
VI  - 82
IP  - 1
DP  - 2018 Jan
TI  - Comparison of 3 vaccination strategies against porcine reproductive and 
      respiratory syndrome virus, Mycoplasma hyopneumoniae, and porcine circovirus type 
      2 on a 3 pathogen challenge model.
PG  - 39-47
AB  - The objective of this study was to compare clinical, microbiologic, immunologic, 
      and pathologic parameters in pigs each concurrently administered porcine 
      reproductive and respiratory syndrome virus (PRRSV), Mycoplasma hyopneumoniae, 
      and porcine circovirus type 2 (PCV2) vaccine from 1 of 2 commercial sources at 21 
      days of age and challenged with field strains of each of the 3 pathogens. Pigs 
      were challenged with PRRSV and M. hyopneumoniae at 42 days of age (-14 days 
      post-challenge, dpc) followed by a challenge with PCV2 at 56 days of age (0 dpc). 
      Significant differences were observed between vaccinated challenged and 
      unvaccinated challenged groups in clinical (average daily gain and clinical 
      signs), microbiologic (viremia and nasal shedding), immunologic (antibodies and 
      interferon-gamma secreting cells), and pathologic (lesions) outcomes. Significant 
      differences were observed among the 3 vaccinated challenged groups in 
      microbiologic (nasal shedding of M. hyopneumoniae and viremia of PCV2) and 
      immunologic (M. hyopneumoniae- and PCV2-specific interferon-gamma secreting cells) 
      outcomes. The vaccination regimen for PRRSV vaccine, M. hyopneumoniae vaccine, 
      and PCV2 vaccine is efficacious for controlling triple challenge with PRRSV, M. 
      hyopneumoniae, and PCV2 from weaning to finishing period.
FAU - Jeong, Jiwoon
AU  - Jeong J
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Kim, Seeun
AU  - Kim S
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Park, Kee Hwan
AU  - Park KH
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Park, Changhoon
AU  - Park C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Seoul National University, College of Veterinary Medicine, Department of 
      Veterinary Pathology, 1 Gwanak-ro, Gwanak-gu, 151-742, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Canada
TA  - Can J Vet Res
JT  - Canadian journal of veterinary research = Revue canadienne de recherche 
      veterinaire
JID - 8607793
RN  - 0 (Bacterial Vaccines)
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Bacterial Vaccines/administration & dosage/immunology
MH  - Circoviridae Infections/immunology/prevention & control/*veterinary
MH  - *Circovirus/classification/immunology
MH  - DNA, Viral/blood
MH  - Mycoplasma hyopneumoniae/immunology
MH  - Pneumonia of Swine, Mycoplasmal/microbiology/*prevention & control
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control/virology
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - RNA, Viral/blood
MH  - Swine
MH  - Swine Diseases/microbiology/prevention & control/virology
MH  - Time Factors
MH  - Vaccination/*veterinary
MH  - Viral Vaccines/administration & dosage/immunology
MH  - Viremia/veterinary
PMC - PMC5764041
EDAT- 2018/02/01 06:00
MHDA- 2018/08/14 06:00
PMCR- 2018/07/01
CRDT- 2018/02/01 06:00
PHST- 2017/02/03 00:00 [received]
PHST- 2017/05/24 00:00 [accepted]
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/08/14 06:00 [medline]
PHST- 2018/07/01 00:00 [pmc-release]
AID - cjvr_01_39 [pii]
PST - ppublish
SO  - Can J Vet Res. 2018 Jan;82(1):39-47.