PMID- 29383161
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 70
DP  - 2017 Dec 29
TI  - Impact of prenatal cold stress on placental physiology, inflammatory response, 
      and apoptosis in rats.
PG  - 115304-115314
LID - 10.18632/oncotarget.23257 [doi]
AB  - Prenatal cold stress is one of the earliest factors affecting mammalian health, 
      and is associated with neonatal growth retardation and immune dysfunction, thus 
      increasing disease susceptibility. The mechanisms underlying these observations 
      remain unclear; hence, the objective of this study was to elucidate placental 
      responses to cold stress. 60 maternal rats were randomly allocated to either 
      stressed (n = 30) or non-stressed (control, n = 30) treatment conditions and 30 
      pubs (n=15) were used for the pups analysis. We found that maternal exposure to 
      cold stress resulted in decreased body temperature, increased food intake without 
      body weight gain, and a high level of plasma corticosterone (CORT) between 
      gestational day (GD) 14 and GD21. In addition, gestation cold stress induced the 
      placental expression of heat shock protein 70 (HSP70), IkappaBalpha, glucocorticoid 
      receptor (GR), mineralocorticoid receptor (MR), 11beta-hydroxysteroid dehydrogenase 
      2 (11beta-HSD2), interferon (IFN) regulatory factor 3 (IRF3), Caspase-3 proteins and 
      altered the ratio of B-cell lymphoma-extra large (Bcl-xL) to Bcl-associated x 
      (Bax) proteins on gestational GD15, GD17, GD19, and GD21, also resulted in the 
      production of interleukin (IL)-1beta. Next, gestational cold stress provoked a 
      decrease in plasma GH levels of 21-day-old offspring, and the body weights of 
      offspring were have no differences from postnatal day (PD) 1-21. Taken together, 
      our results indicate that gestational cold stress induces placental apoptosis and 
      the activation of NF-kB via HSP70/TLR4/NF-kappaB signaling pathways in the placenta, 
      these changes may affect placental function and fetus development.
FAU - Lian, Shuai
AU  - Lian S
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Guo, Jingru
AU  - Guo J
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Wang, Lipeng
AU  - Wang L
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Li, Wenjie
AU  - Li W
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Wang, Jianfa
AU  - Wang J
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Ji, Hong
AU  - Ji H
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Kong, Fanzhi
AU  - Kong F
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Xu, Bin
AU  - Xu B
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Li, Shize
AU  - Li S
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
FAU - Yang, Huanmin
AU  - Yang H
AD  - College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural 
      University, Daqing 163319, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20171214
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5777773
OTO - NOTNLM
OT  - NF-kappaB
OT  - apoptosis
OT  - inflammatory
OT  - placental
OT  - prenatal cold stress
COIS- CONFLICTS OF INTEREST The authors declare no competing financial interest.
EDAT- 2018/02/01 06:00
MHDA- 2018/02/01 06:01
PMCR- 2017/12/29
CRDT- 2018/02/01 06:00
PHST- 2017/09/04 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/01 06:01 [medline]
PHST- 2017/12/29 00:00 [pmc-release]
AID - 23257 [pii]
AID - 10.18632/oncotarget.23257 [doi]
PST - epublish
SO  - Oncotarget. 2017 Dec 14;8(70):115304-115314. doi: 10.18632/oncotarget.23257. 
      eCollection 2017 Dec 29.