PMID- 29383806
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 19
IP  - 4
DP  - 2018 Jun
TI  - Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes 
      mellitus in Taiwan.
PG  - 699-706
LID - 10.1111/pedi.12645 [doi]
AB  - BACKGROUND: Type 1 diabetes (T1D) mellitus is an autoimmune disorder involving 
      both complex genetic and environmental factors. The incidence rates are low in 
      Asian countries, and the specific, explanatory genetic factors underlying this 
      have been investigated. The aim of this study was to elucidate the association of 
      human leukocyte antigen (HLA) alleles/haplotypes with T1D in Taiwan. METHODS: We 
      performed direct comprehensive genotyping of 6 classical HLA loci (HLA-A, -B, -C, 
      -DPB1, -DQB1, and -DRB1) to 4-digit resolution in 104 unrelated T1D patients and 
      504 controls. Twenty-four of the 104 patients also exhibited thyroid 
      autoimmunity. RESULTS: Three major susceptibility haplotypes were identified: 
      DRB1*03:01-DQB1*02:01 (odds ratio [OR] = 5.39 under the dominant model, 
      P = 2.3 x 10(-13) ), DRB1*04:05-DQB1*04:01 (OR = 2.44, P = 5.0 x 10(-4) ), and 
      DRB1*09:01-DQB1*03:03 (OR = 2.02, P = 1.4 x 10(-3) ); one protective haplotype 
      was identified: DRB1*08:03-DQB1*06:01 (OR = 0.10, P = 1.6 x 10(-3) ). 
      DRB1*03:01-DQB1*02:01, the major T1D susceptibility haplotype, was found at a 
      lower frequency in T1D patients with thyroid autoimmunity. The T1D protective 
      allele DRB1*12:02 was shown to be protective against Graves' disease in our 
      previous report. CONCLUSION: In addition to clarifying the roles of several known 
      T1D HLA alleles and haplotypes, we discovered that the DRB1*08:03-DQB1*06:01 
      haplotype is protective against T1D. The DRB1*12:02 allele protected against both 
      T1D and Graves' disease.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Tung, Yi-Ching
AU  - Tung YC
AUID- ORCID: 0000-0003-0466-3891
AD  - Department of Pediatrics, National Taiwan University Hospital and College of 
      Medicine, National Taiwan University, Taipei, Taiwan.
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Fann, Cathy S-J
AU  - Fann CS
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Chang, Chien-Ching
AU  - Chang CC
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Chu, Chen-Chung
AU  - Chu CC
AD  - Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
FAU - Yang, Wei-Shiung
AU  - Yang WS
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Department of Internal Medicine, College of Medicine, National Taiwan University, 
      Taipei, Taiwan.
AD  - Graduate Institute of Medical Genomics and Proteomics, College of Medicine, 
      National Taiwan University, Taipei, Taiwan.
FAU - Hwu, Wuh-Liang
AU  - Hwu WL
AD  - Department of Pediatrics, National Taiwan University Hospital and College of 
      Medicine, National Taiwan University, Taipei, Taiwan.
AD  - Department of Medical Genetics, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Chen, Pei-Lung
AU  - Chen PL
AD  - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
AD  - Graduate Institute of Medical Genomics and Proteomics, College of Medicine, 
      National Taiwan University, Taipei, Taiwan.
AD  - Department of Medical Genetics, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Tsai, Wen-Yu
AU  - Tsai WY
AD  - Department of Pediatrics, National Taiwan University Hospital and College of 
      Medicine, National Taiwan University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20180131
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Genotyping Techniques/methods
MH  - Graves Disease/epidemiology/genetics
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Testing/methods
MH  - Humans
MH  - Male
MH  - Taiwan/epidemiology
MH  - Thyroiditis, Autoimmune/epidemiology/genetics
OTO - NOTNLM
OT  - HLA
OT  - association study
OT  - autoimmunity
OT  - haplotype
OT  - type 1 diabetes
EDAT- 2018/02/01 06:00
MHDA- 2019/02/13 06:00
CRDT- 2018/02/01 06:00
PHST- 2017/11/08 00:00 [received]
PHST- 2017/12/11 00:00 [revised]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2018/02/01 06:00 [entrez]
AID - 10.1111/pedi.12645 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2018 Jun;19(4):699-706. doi: 10.1111/pedi.12645. Epub 2018 Jan 
      31.