PMID- 29384866
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 97
IP  - 5
DP  - 2018 Feb
TI  - Association between TNF-alpha-238G/A gene polymorphism and OCD susceptibility: A 
      meta-analysis.
PG  - e9769
LID - 10.1097/MD.0000000000009769 [doi]
LID - e9769
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is an important cytokine and has 
      been reported to be associated with the pathogenesis of many autoimmune and 
      inflammatory diseases. TNF-alpha gene is located on a region that has been found to 
      be associated with obsessive-compulsive disorder (OCD). We performed this 
      meta-analysis to assess the relationship between susceptibility to OCD and the 
      TNF-alpha-238G/A gene polymorphism. METHODS: An extensive search of the available 
      literature on the association between the susceptibility to OCD and the TNF gene 
      polymorphism was conducted by searching PubMed, Web of Knowledge, Embase, Chinese 
      Web of Knowledge, Wanfang, and Chongqing VIP database. The database was searched 
      up to December 2016 and includes language of English and/or Chinese with the 
      keywords of "obsessive-compulsive disorder" or "OCD," polymorphism or variant or 
      mutation, "tumor necrosis factor" or "TNF" or "cytokine." The association between 
      TNF-alpha-238G/A gene polymorphism and the susceptibility of OCD was anticipated by 
      odds ratio (OR) with the corresponding 95% confidence interval (95% CI). RESULTS: 
      Four studies including 435 cases and 1073 controls were incorporated in our 
      meta-analysis. In general, TNF-alpha-238G/A gene polymorphism might lead to a 
      decreased risk of OCD susceptibility (G vs A genotype model: OR = 1.01, 95% 
      CI = 0.37-2.77, P = .981; GG vs AA+AG model: OR = 0.93, 95% CI = 0.37-2.36, 
      P = .879; GG+AG vs AA model: OR = 0.22, 95% CI = 0.06-0.73, P = .014; GG vs AA 
      model: OR = 0.21, 95% CI = 0.06-0.71, P = .012; AG vs AA model: OR = 0.29, 95% 
      CI = 0.07-1.16, P = .081; GG+AA vs AG model: OR = 1.17, 95% CI = 0.55-2.51, 
      P = .683). CONCLUSION: TNF-alpha-238G/A gene polymorphism might lead to a decreased 
      risk of OCD susceptibility.
FAU - Jiang, Caixiao
AU  - Jiang C
AD  - Hebei Center for Disease Control and Prevention Shijiazhuang Center for Disease 
      Control and Prevention, Hebei Province, China.
FAU - Ma, Xinyan
AU  - Ma X
FAU - Qi, Shunxiang
AU  - Qi S
FAU - Han, Guangyue
AU  - Han G
FAU - Li, Yan
AU  - Li Y
FAU - Liu, Yanfang
AU  - Liu Y
FAU - Liu, Lanfen
AU  - Liu L
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Obsessive-Compulsive Disorder/*genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
PMC - PMC5805438
COIS- The author(s) declare no competing financial interests.
EDAT- 2018/02/01 06:00
MHDA- 2018/02/10 06:00
PMCR- 2018/02/02
CRDT- 2018/02/01 06:00
PHST- 2018/02/01 06:00 [entrez]
PHST- 2018/02/01 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
PHST- 2018/02/02 00:00 [pmc-release]
AID - 00005792-201802020-00028 [pii]
AID - MD-D-17-03490 [pii]
AID - 10.1097/MD.0000000000009769 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2018 Feb;97(5):e9769. doi: 10.1097/MD.0000000000009769.