PMID- 29386128
OWN - NLM
STAT- MEDLINE
DCOM- 20190715
LR  - 20190715
IS  - 2211-1247 (Electronic)
VI  - 22
IP  - 4
DP  - 2018 Jan 23
TI  - Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human 
      Subcutaneous White Adipose Tissue in Women and Men with Obesity.
PG  - 1079-1089
LID - S2211-1247(17)31954-X [pii]
LID - 10.1016/j.celrep.2017.12.102 [doi]
AB  - Caloric restriction (CR) is standard lifestyle therapy in obesity management. 
      CR-induced weight loss improves the metabolic profile of individuals with 
      obesity. In mice, occurrence of beige fat cells in white fat depots favors a 
      metabolically healthy phenotype, and CR promotes browning of white adipose tissue 
      (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 
      individuals with obesity following a two-phase dietary intervention consisting of 
      an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before 
      the intervention, we show sex differences and seasonal variation, with higher 
      expression of brown and beige markers in women with obesity and during winter, 
      respectively. The very low calorie diet resulted in decreased browning of 
      subcutaneous abdominal WAT. During the whole dietary intervention, evolution of 
      body fat and insulin resistance was independent of changes in brown and beige fat 
      markers. These data suggest that diet-induced effects on body fat and insulin 
      resistance are independent of subcutaneous abdominal WAT browning in people with 
      obesity.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Barquissau, Valentin
AU  - Barquissau V
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Leger, Benjamin
AU  - Leger B
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Beuzelin, Diane
AU  - Beuzelin D
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Martins, Frederic
AU  - Martins F
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Amri, Ez-Zoubir
AU  - Amri EZ
AD  - University of Cote d'Azur, CNRS, Inserm, iBV, Nice, France.
FAU - Pisani, Didier F
AU  - Pisani DF
AD  - University of Cote d'Azur, CNRS, Inserm, iBV, Nice, France.
FAU - Saris, Wim H M
AU  - Saris WHM
AD  - Department of Human Biology, NUTRIM School of Nutrition and Translational 
      Research in Metabolism, Maastricht University Medical Centre, Maastricht, the 
      Netherlands.
FAU - Astrup, Arne
AU  - Astrup A
AD  - Department of Nutrition, Exercise and Sports, Faculty of Sciences, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Maoret, Jean-Jose
AU  - Maoret JJ
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Iacovoni, Jason
AU  - Iacovoni J
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Dejean, Sebastien
AU  - Dejean S
AD  - University of Toulouse, Paul Sabatier University, Toulouse, France; CNRS, UMR 
      5219, Toulouse Mathematics Institute, Toulouse, France.
FAU - Moro, Cedric
AU  - Moro C
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Viguerie, Nathalie
AU  - Viguerie N
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France.
FAU - Langin, Dominique
AU  - Langin D
AD  - INSERM, UMR 1048, Institute of Metabolic and Cardiovascular Diseases, Toulouse, 
      France; University of Toulouse, Paul Sabatier University, Toulouse, France; 
      Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, 
      France. Electronic address: dominique.langin@inserm.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180128
PL  - United States
TA  - Cell Rep
JT  - Cell reports
JID - 101573691
SB  - IM
CIN - Trends Endocrinol Metab. 2018 Jul;29(7):450-452. PMID: 29548805
MH  - Adipose Tissue, White/*metabolism
MH  - Animals
MH  - Caloric Restriction/*methods
MH  - Diet, Reducing/*methods
MH  - Humans
MH  - Male
MH  - Mice
MH  - Obesity/*genetics/metabolism
MH  - Subcutaneous Fat/*metabolism
MH  - Weight Loss/*physiology
OTO - NOTNLM
OT  - browning of white fat
OT  - caloric restriction
OT  - dietary intervention
OT  - human obesity
OT  - insulin resistance
OT  - sex difference
OT  - subcutaneous abdominal white adipose tissue
OT  - uncoupling protein 1
EDAT- 2018/02/02 06:00
MHDA- 2019/07/16 06:00
CRDT- 2018/02/02 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2017/10/18 00:00 [revised]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2019/07/16 06:00 [medline]
AID - S2211-1247(17)31954-X [pii]
AID - 10.1016/j.celrep.2017.12.102 [doi]
PST - ppublish
SO  - Cell Rep. 2018 Jan 23;22(4):1079-1089. doi: 10.1016/j.celrep.2017.12.102. Epub 
      2018 Jan 28.