PMID- 29386248
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20220408
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 41
IP  - 9
DP  - 2018 Sep
TI  - Trends in Hospital Admission for Diabetic Ketoacidosis in Adults With Type 1 and 
      Type 2 Diabetes in England, 1998-2013: A Retrospective Cohort Study.
PG  - 1870-1877
LID - 10.2337/dc17-1583 [doi]
AB  - OBJECTIVE: This study determined trends in hospital admission for diabetic 
      ketoacidosis (DKA) in adults with type 1 diabetes mellitus (T1DM) and type 2 
      diabetes mellitus (T2DM) from 1998 to 2013 in England. RESEARCH DESIGN AND 
      METHODS: The study population included 23,246 adults with T1DM and 241,441 adults 
      with T2DM from the Clinical Practice Research Datalink (CPRD) and Hospital 
      Episode Statistics (HES). All hospital admissions for DKA as the primary 
      diagnosis from 1998 to 2013 were identified. Trends in hospital admission for DKA 
      in incidence, length of hospital stay, 30-day all-cause readmission rate, and 
      30-day and 1-year all-cause mortality rates were determined using joinpoint 
      regression, negative binomial regression, and logistic regression models. 
      RESULTS: For T1DM, the incidence of hospital admission for DKA increased between 
      1998 and 2007 and remained static until 2013. The incidence in 2013 was higher 
      than that in 1998 (incidence rate ratio 1.53 [95% CI 1.09-2.16]). For T2DM, the 
      incidence increased 4.24% (2.82-5.69) annually between 1998 and 2013. The length 
      of hospital stay decreased over time for both diabetes types (P </= 0.0004). Adults 
      with T1DM were more likely to be discharged within 2 days compared with adults 
      with T2DM (odds ratio [OR] 1.28 [1.07-1.53]). The 30-day readmission rate was 
      higher in T1DM than in T2DM (OR 1.61 [1.04-2.50]) but remained unchanged for both 
      diabetes types over time. Trends in 30-day and 1-year all-cause mortality rates 
      were also stable, with no difference by diabetes type. CONCLUSIONS: In the 
      previous two decades in England, hospitalization for DKA increased in adults with 
      T1DM and in those with T2DM, and associated health care performance did not 
      improve except decreased length of hospital stay.
CI  - (c) 2018 by the American Diabetes Association.
FAU - Zhong, Victor W
AU  - Zhong VW
AD  - Department of Nutrition, Gillings School of Global Public Health, University of 
      North Carolina, Chapel Hill, NC.
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, Chicago, IL.
FAU - Juhaeri, Juhaeri
AU  - Juhaeri J
AD  - Global Pharmacovigilance and Epidemiology, Sanofi US, Bridgewater, NJ.
FAU - Mayer-Davis, Elizabeth J
AU  - Mayer-Davis EJ
AUID- ORCID: 0000-0003-3858-0517
AD  - Department of Nutrition, Gillings School of Global Public Health, University of 
      North Carolina, Chapel Hill, NC mayerdav@email.unc.edu.
AD  - Department of Medicine, School of Medicine, University of North Carolina, Chapel 
      Hill, NC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180131
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
CIN - Diabetes Care. 2018 Sep;41(9):1839-1841. PMID: 30135197
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diabetes Mellitus, Type 1/complications/*epidemiology
MH  - Diabetes Mellitus, Type 2/complications/*epidemiology
MH  - Diabetic Ketoacidosis/*epidemiology/etiology
MH  - England/epidemiology
MH  - Female
MH  - Hospitalization/statistics & numerical data/trends
MH  - Humans
MH  - Incidence
MH  - Length of Stay/statistics & numerical data/trends
MH  - Male
MH  - Middle Aged
MH  - Patient Admission/statistics & numerical data/*trends
MH  - Patient Discharge/statistics & numerical data
MH  - Patient Readmission/statistics & numerical data/trends
MH  - Retrospective Studies
EDAT- 2018/02/02 06:00
MHDA- 2018/10/12 06:00
CRDT- 2018/02/02 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/12/30 00:00 [accepted]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2018/02/02 06:00 [entrez]
AID - dc17-1583 [pii]
AID - 10.2337/dc17-1583 [doi]
PST - ppublish
SO  - Diabetes Care. 2018 Sep;41(9):1870-1877. doi: 10.2337/dc17-1583. Epub 2018 Jan 
      31.