PMID- 29386485
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20201209
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 41
IP  - 2
DP  - 2018
TI  - Juniperus chinensis Fruits Attenuate Oxazolone- and 
      2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms in Mice.
PG  - 259-265
LID - 10.1248/bpb.b17-00818 [doi]
AB  - Juniperus chinensis, commonly Chinese juniper, has been used for treating 
      inflammatory diseases. This study aimed to investigate anti-atopic dermatitis 
      (AD) effects of standardized J. chinensis fruits extract on murine oxazolone- and 
      2,4-dinitrochlorobenzene (DNCB)-induced models of AD. Ear swelling, epidermis 
      thickening, and eosinophils infiltration in the oxazolone-mediated dermatitis of 
      BALB/c mice were significantly reduced upon topical application of J. chinensis 
      fruits 95% EtOH extract (JCE). Besides, transdermal administration of JCE to 
      SKH-1 hairless mice inhibited the development of DNCB-induced AD-like skin 
      lesions by suppressing transepidermal water loss and improving skin hydration. 
      Decreased total serum immunoglobulin E (IgE) and interleukin (IL)-4 levels could 
      be observed in atopic dorsal skin samples of JCE-treated group. According to the 
      phytochemical analysis, JCE was found to contain 
      isoscutellarein-7-O-beta-D-xyloside, cupressuflavone, and amentoflavone as main 
      compounds. Therapeutic attempts with the J. chinensis fruits might be useful in 
      the treatment of AD and related skin inflammatory diseases.
FAU - Jegal, Jonghwan
AU  - Jegal J
AD  - College of Pharmacy, Pusan National University.
FAU - Park, No-June
AU  - Park NJ
AD  - College of Pharmacy, Pusan National University.
FAU - Park, Sang-A
AU  - Park SA
AD  - College of Pharmacy, Pusan National University.
FAU - Bong, Sim-Kyu
AU  - Bong SK
AD  - Natural Products Research Institute, Korea Institute of Science and Technology.
FAU - Jegal, Hyun
AU  - Jegal H
AD  - Natural Products Research Institute, Korea Institute of Science and Technology.
FAU - Kim, Su-Nam
AU  - Kim SN
AD  - Natural Products Research Institute, Korea Institute of Science and Technology.
FAU - Yang, Min Hye
AU  - Yang MH
AD  - College of Pharmacy, Pusan National University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biflavonoids)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Flavonoids)
RN  - 0 (Glycosides)
RN  - 0 (Irritants)
RN  - 0 (Plant Extracts)
RN  - 15646-46-5 (Oxazolone)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adjuvants, Immunologic/toxicity
MH  - Administration, Cutaneous
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & 
      dosage/analysis/chemistry/*therapeutic use
MH  - Biflavonoids/administration & dosage/analysis/chemistry/therapeutic use
MH  - Dermatitis, Atopic/chemically induced/immunology/pathology/*prevention & control
MH  - Dinitrochlorobenzene/toxicity
MH  - Female
MH  - Flavonoids/administration & dosage/analysis/chemistry/therapeutic use
MH  - Fruit/*chemistry/growth & development
MH  - Glycosides/administration & dosage/analysis/chemistry/therapeutic use
MH  - Immunoglobulin E/analysis
MH  - Interleukin-4/blood
MH  - Irritants/toxicity
MH  - Juniperus/*chemistry/growth & development
MH  - Mice, Hairless
MH  - Mice, Inbred BALB C
MH  - Molecular Structure
MH  - Oxazolone/toxicity
MH  - *Phytotherapy
MH  - Plant Extracts/administration & dosage/chemistry/*therapeutic use
MH  - Republic of Korea
MH  - Skin/*drug effects/immunology/metabolism/pathology
OTO - NOTNLM
OT  - Juniperus chinensis fruit
OT  - atopic dermatitis
OT  - immunoglobulin E
OT  - interleukin 4
OT  - skin hydration
OT  - transepidermal water loss
EDAT- 2018/02/02 06:00
MHDA- 2018/08/22 06:00
CRDT- 2018/02/02 06:00
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
AID - 10.1248/bpb.b17-00818 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2018;41(2):259-265. doi: 10.1248/bpb.b17-00818.