PMID- 29387021
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1664-0640 (Print)
IS  - 1664-0640 (Electronic)
IS  - 1664-0640 (Linking)
VI  - 8
DP  - 2017
TI  - Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from 
      Meta-Analyses.
PG  - 308
LID - 10.3389/fpsyt.2017.00308 [doi]
LID - 308
AB  - Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) is 
      associated with the pathophysiology of major depressive disorder (MDD). In this 
      mini review, we explored the association between BDNF and MDD using meta-analytic 
      evidence. Our findings indicated that the Val66Met polymorphism in the BDNF gene 
      was not associated with MDD or hippocampal volume in patients with MDD. However, 
      plasma/serum levels of BDNF were decreased in patients with acute MDD compared 
      with healthy controls. Both antidepressant treatment and electroconvulsive 
      therapy increased plasma and serum levels of BDNF in patients with MDD. Val66Met 
      polymorphism in the BDNF gene was associated with an antidepressant response in 
      patients with MDD. Taken together, we did not detect any plausible evidence 
      regarding Val66Met polymorphism in the BDNF gene contributing to a risk of MDD. 
      However, peripheral BDNF levels are decreased in patients with MDD, and the 
      polymorphisms are associated with treatment response. In conclusion, BDNF is best 
      understood to be a biomarker for the state of MDD and its treatment response 
      rather than a risk factor for MDD.
FAU - Kishi, Taro
AU  - Kishi T
AD  - Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
FAU - Yoshimura, Reiji
AU  - Yoshimura R
AD  - Department of Psychiatry, University of Occupational and Environmental Health, 
      Kitakyushu, Japan.
FAU - Ikuta, Toshikazu
AU  - Ikuta T
AD  - Department of Communication Sciences and Disorders, School of Applied Sciences, 
      University of Mississippi, University, MS, United States.
FAU - Iwata, Nakao
AU  - Iwata N
AD  - Department of Psychiatry, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180117
PL  - Switzerland
TA  - Front Psychiatry
JT  - Frontiers in psychiatry
JID - 101545006
PMC - PMC5776079
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - major depressive disorder
OT  - meta-analysis
OT  - pathophysiology
OT  - umbrella review
EDAT- 2018/02/02 06:00
MHDA- 2018/02/02 06:01
PMCR- 2018/01/17
CRDT- 2018/02/02 06:00
PHST- 2017/11/08 00:00 [received]
PHST- 2017/12/22 00:00 [accepted]
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/02/02 06:01 [medline]
PHST- 2018/01/17 00:00 [pmc-release]
AID - 10.3389/fpsyt.2017.00308 [doi]
PST - epublish
SO  - Front Psychiatry. 2018 Jan 17;8:308. doi: 10.3389/fpsyt.2017.00308. eCollection 
      2017.