PMID- 29387206
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220321
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 1
DP  - 2018 Jan
TI  - Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial 
      biogenesis and lipid metabolism via Sirtuin type 1.
PG  - 576-584
LID - 10.3892/etm.2017.5400 [doi]
AB  - The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health 
      problem and novel therapeutic strategies are required to prevent and treat T2DM. 
      It has been demonstrated that resveratrol (RSV) may prevent T2DM by targeting 
      Sirtuin type 1 (SIRT1), indicating that SIRT1 may be a novel therapeutic target 
      for T2DM prevention. In the present study, a T2DM rat model was established by 
      administering a high fat diet and streptozotocin (STZ) injections. Measurements 
      of blood glucose and insulin confirmed successful establishment of the T2DM 
      model. RSV was used to treat rats with STZ-induced T2DM and the results indicated 
      that RSV reversed the STZ-induced downregulation of peroxisome 
      proliferator-activated receptor-gamma coactivator-1alpha, SIRT1 and forkhead box protein 
      O 3a. Furthermore, RSV modulated the activity of superoxide dismutase and 
      malondialdehyde, which are associated with oxidative stress. In vitro, cells from 
      the insulinoma cell line clone 1E were pretreated with palmitic acid (PA) to 
      simulate a high fat environment. The results of reverse 
      transcription-quantitative polymerase chain reaction indicated that PA suppressed 
      the expression of SIRT1 in a dose- and time-dependent manner. Furthermore, PA 
      modulated the expression of mitochondrial biogenesis-associated, lipid 
      metabolism-associated and beta-cell-associated genes, whereas RSV treatment 
      ameliorated the PA-induced changes in the expression of these genes via SIRT1. 
      The results of the present study suggest that RSV participates in the prevention 
      of T2DM by regulating the expression of mitochondrial genes associated with 
      biogenesis, lipid metabolism and beta-cells via SIRT1. The results of the current 
      study provide an insight into the mechanisms by which SIRT1 inhibits T2DM and may 
      be used as a basis for future studies.
FAU - Cao, Ming-Ming
AU  - Cao MM
AD  - Department of Endocrinology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Lu, Xi
AU  - Lu X
AD  - Department of Gastroenterology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Liu, Guo-Dong
AU  - Liu GD
AD  - Department of Endocrinology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Su, Ying
AU  - Su Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Li, Yan-Bo
AU  - Li YB
AD  - Department of Endocrinology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Zhou, Jin
AU  - Zhou J
AD  - Department of Hematology, The First Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20171030
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5769236
OTO - NOTNLM
OT  - insulin resistance
OT  - lipid metabolism
OT  - mitochondrial biogenesis
OT  - resveratrol
OT  - sirtuin type 1
OT  - type 2 diabetes mellitus
EDAT- 2018/02/02 06:00
MHDA- 2018/02/02 06:01
PMCR- 2017/10/30
CRDT- 2018/02/02 06:00
PHST- 2017/01/04 00:00 [received]
PHST- 2017/08/24 00:00 [accepted]
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/02/02 06:01 [medline]
PHST- 2017/10/30 00:00 [pmc-release]
AID - ETM-0-0-5400 [pii]
AID - 10.3892/etm.2017.5400 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Jan;15(1):576-584. doi: 10.3892/etm.2017.5400. Epub 2017 Oct 
      30.