PMID- 29387732
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20181113
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2017
DP  - 2017
TI  - Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic 
      Asthma.
PG  - 5134760
LID - 10.1155/2017/5134760 [doi]
LID - 5134760
AB  - Dendritic cells (DCs) are highly specialized in antigen presentation and play a 
      pivotal role in the initiation, progression, and perpetuation of adaptive immune 
      responses. Emerging immune pathways are being recognized increasingly for DCs and 
      their subsets that differentially regulate T lymphocyte function based on the 
      type and interactions with the antigen. However, these interactions not only 
      alter the signaling process and DC function but also render metabolic plasticity. 
      The current review focuses on the metabolic cues of DCs that coordinate DC 
      activation and differentiation and discuss whether targeting these fundamental 
      cellular processes have implications to control airway inflammation and adaptive 
      immunity. Therefore, strategies using metabolism-based therapeutic manipulation 
      of DC functions could be developed into novel treatments for airway inflammation 
      and asthma.
FAU - Mishra, Amarjit
AU  - Mishra A
AUID- ORCID: 0000-0002-3777-0338
AD  - Department of Pathobiology, College of Veterinary Medicine, 254 Greene Hall, 
      Auburn University, Auburn, AL 36849, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171214
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
SB  - IM
MH  - Animals
MH  - Antigen Presentation
MH  - Asthma/*immunology
MH  - Cell Differentiation
MH  - Cell Plasticity
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunomodulation
MH  - Immunotherapy/*methods
MH  - Lymphocyte Activation
MH  - T-Lymphocytes/*immunology
PMC - PMC5745769
EDAT- 2018/02/02 06:00
MHDA- 2018/08/17 06:00
PMCR- 2017/12/14
CRDT- 2018/02/02 06:00
PHST- 2017/08/22 00:00 [received]
PHST- 2017/11/07 00:00 [accepted]
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/12/14 00:00 [pmc-release]
AID - 10.1155/2017/5134760 [doi]
PST - ppublish
SO  - J Immunol Res. 2017;2017:5134760. doi: 10.1155/2017/5134760. Epub 2017 Dec 14.