PMID- 29388365
OWN - NLM
STAT- MEDLINE
DCOM- 20190429
LR  - 20190429
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 6
IP  - 2
DP  - 2018 Jun
TI  - Collagen-derived peptides modulate CD4(+) T-cell differentiation and suppress 
      allergic responses in mice.
PG  - 245-255
LID - 10.1002/iid3.213 [doi]
AB  - INTRODUCTION: Collagen peptides have been widely used as a food supplement. After 
      ingestion of collagen peptides, oligopeptides containing hydroxyproline (Hyp), 
      which are known to have some physiological activities, are detected in peripheral 
      blood. However, the effects of collagen-peptide administration on immune response 
      are unclear. In the present study, we tested the effects of collagen-peptide 
      ingestion on allergic response and the effects of collagen-derived oligopeptides 
      on CD4(+) T-cell differentiation. METHODS: BALB/c mice fed a collagen-peptide 
      diet were immunized with ovalbumin (OVA), and their serum IgE and IgG levels, 
      active cutaneous anaphylaxis, and cytokine secretion by splenocytes were 
      examined. Naive CD4(+) T cells were stimulated with anti-CD3 and anti-CD28 in the 
      presence of collagen-derived oligopeptides, and the expression of IFN-gamma, IL-4, 
      and Foxp3 was analyzed. RESULTS: In an active anaphylaxis model, oral 
      administration of collagen peptides suppressed serum OVA-specific immunoglobulin 
      E (IgE) production and diminished anaphylaxis responses. In this model, the 
      ingestion of collagen peptides skewed the pattern of cytokine production by 
      splenocytes toward T-helper (Th) type 1 and regulatory T (Treg) cells. In vitro 
      T-helper cell differentiation assays showed that Hyp-containing oligopeptides 
      promoted Th1 differentiation by upregulating IFN-gamma-induced signal transducer and 
      activator of transcription 1 (STAT1) signaling. These oligopeptides also promoted 
      the development of Foxp3(+) Treg cells in response to antigen stimulation in the 
      presence of TGF-beta. CONCLUSIONS: Collagen-peptide ingestion suppresses allergic 
      responses by skewing the balance of CD4(+) T cells toward Th1 and Treg cells and 
      seems to be a promising agent for preventing allergies and inflammatory diseases.
CI  - (c) 2018 The Authors. Immunity, Inflammation and Disease Published by John Wiley & 
      Sons Ltd.
FAU - Nishikimi, Akihiko
AU  - Nishikimi A
AUID- ORCID: 0000-0001-9497-7557
AD  - Department of Biosciences, School of Science, Kitasato University, Sagamihara, 
      Kanagawa, Japan.
FAU - Koyama, Yoh-Ichi
AU  - Koyama YI
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
AD  - Institute for Animal Reproduction, Kasumigaura, Ibaraki, Japan.
FAU - Ishihara, Sayaka
AU  - Ishihara S
AD  - Department of Biosciences, School of Science, Kitasato University, Sagamihara, 
      Kanagawa, Japan.
FAU - Kobayashi, Shusaku
AU  - Kobayashi S
AD  - Department of Biosciences, School of Science, Kitasato University, Sagamihara, 
      Kanagawa, Japan.
FAU - Tometsuka, Chisa
AU  - Tometsuka C
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
FAU - Kusubata, Masashi
AU  - Kusubata M
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
FAU - Kuwaba, Kumiko
AU  - Kuwaba K
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
FAU - Hayashida, Osamu
AU  - Hayashida O
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
FAU - Hattori, Shunji
AU  - Hattori S
AD  - Research Institute of Biomatrix, Nippi Inc., Toride, Ibaraki, Japan.
FAU - Katagiri, Koko
AU  - Katagiri K
AD  - Department of Biosciences, School of Science, Kitasato University, Sagamihara, 
      Kanagawa, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180201
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (Peptides)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Administration, Oral
MH  - Anaphylaxis/blood/diet therapy/immunology/*prevention & control
MH  - Animals
MH  - Cell Differentiation/drug effects/immunology
MH  - Collagen/*administration & dosage/immunology
MH  - *Dietary Supplements
MH  - Disease Models, Animal
MH  - Humans
MH  - Immunoglobulin E/blood/immunology
MH  - Lymphocyte Activation/drug effects/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Ovalbumin/immunology
MH  - Peptides/administration & dosage/immunology
MH  - T-Lymphocytes, Regulatory/*drug effects/immunology
MH  - Th1 Cells/*drug effects/immunology
PMC - PMC5946155
OTO - NOTNLM
OT  - Active cutaneous anaphylaxis model
OT  - T cells
OT  - collagen peptide
EDAT- 2018/02/02 06:00
MHDA- 2019/04/30 06:00
PMCR- 2018/02/01
CRDT- 2018/02/02 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2017/12/04 00:00 [revised]
PHST- 2017/12/09 00:00 [accepted]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2019/04/30 06:00 [medline]
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - IID3213 [pii]
AID - 10.1002/iid3.213 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2018 Jun;6(2):245-255. doi: 10.1002/iid3.213. Epub 2018 Feb 1.