PMID- 29388475
OWN - NLM
STAT- MEDLINE
DCOM- 20190909
LR  - 20190909
IS  - 1465-3656 (Electronic)
IS  - 1355-4794 (Linking)
VI  - 24
IP  - 1
DP  - 2018 Feb
TI  - Massive weight loss following deep brain stimulation of the nucleus accumbens in 
      a depressed woman.
PG  - 49-53
LID - 10.1080/13554794.2018.1431678 [doi]
AB  - Obese individuals share behavioral characteristics with drug/alcohol addicts as 
      well as obsessive compulsive disease. Deep brain stimulation (DBS) has been used 
      successfully in these disorders, thus warranting an evaluation in obesity. A 
      woman with treatment-resistant depression as well as severe obesity was selected 
      for DBS of the nucleus accumbens (NAcc) bilaterally with depression being the 
      primary and obesity being the secondary target of treatment. Compared to earlier 
      bariatric surgery, the patient showed accelerated weight loss after DBS. Also, 
      depression was significantly reduced. The current case suggests that DBS of the 
      NAcc warrants further evaluation in patients unresponsive to other treatments.
FAU - Tronnier, Volker M
AU  - Tronnier VM
AD  - a Department of Neurosurgery , University of Lubeck , Lubeck , Germany.
FAU - Rasche, Dirk
AU  - Rasche D
AD  - a Department of Neurosurgery , University of Lubeck , Lubeck , Germany.
FAU - Thorns, Veronika
AU  - Thorns V
AD  - b Department of Psychiatry , University of Lubeck , Lubeck , Germany.
FAU - Alvarez-Fischer, Daniel
AU  - Alvarez-Fischer D
AD  - b Department of Psychiatry , University of Lubeck , Lubeck , Germany.
AD  - c Institute of Neurogenetics , University of Lubeck , Lubeck , Germany.
FAU - Munte, Thomas F
AU  - Munte TF
AUID- ORCID: 0000-0001-9843-2124
AD  - d Department of Neurology , University of Lubeck , Lubeck , Germany.
AD  - e Institute of Psychology II , University of Lubeck , Lubeck , Germany.
FAU - Zurowski, Bartosz
AU  - Zurowski B
AD  - b Department of Psychiatry , University of Lubeck , Lubeck , Germany.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180201
PL  - England
TA  - Neurocase
JT  - Neurocase
JID - 9511374
SB  - IM
MH  - Adult
MH  - Body Weight/physiology
MH  - Deep Brain Stimulation/*adverse effects
MH  - Depression/diagnostic imaging/psychology/*therapy
MH  - Female
MH  - Humans
MH  - Life Style
MH  - Magnetic Resonance Imaging
MH  - Nucleus Accumbens/*physiology
MH  - Surveys and Questionnaires
MH  - Weight Loss/*physiology
OTO - NOTNLM
OT  - Deep brain stimulation
OT  - depression
OT  - incentive salience
OT  - nucleus accumbens
OT  - obesity
OT  - reward
EDAT- 2018/02/02 06:00
MHDA- 2019/09/10 06:00
CRDT- 2018/02/02 06:00
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2019/09/10 06:00 [medline]
PHST- 2018/02/02 06:00 [entrez]
AID - 10.1080/13554794.2018.1431678 [doi]
PST - ppublish
SO  - Neurocase. 2018 Feb;24(1):49-53. doi: 10.1080/13554794.2018.1431678. Epub 2018 
      Feb 1.