PMID- 29389519
OWN - NLM
STAT- MEDLINE
DCOM- 20190109
LR  - 20190109
IS  - 1878-0814 (Electronic)
IS  - 1877-1173 (Linking)
VI  - 153
DP  - 2018 Jan
TI  - Chemical Modulation of WNT Signaling in Cancer.
PG  - 245-269
LID - S1877-1173(17)30186-2 [pii]
LID - 10.1016/bs.pmbts.2017.11.008 [doi]
AB  - Genetically based observations stemming from defects in development and in 
      regeneration form the foundation of our understanding regarding how the secreted 
      WNT proteins control coordinated cell fate decision-making in adult tissues. At 
      the same time, our anticipation of potential benefits and unwanted toxicities 
      associated with candidate anticancer agents targeting WNT signal transduction are 
      also reliant upon this blueprint of WNT-associated physiology. Despite the long 
      established role of WNT signaling in cancer, the emergence of WNT signaling as a 
      suppressor of immunological attack in melanoma reveals an unanticipated 
      anticancer potential in targeting WNT signaling. Here we review the literature 
      associated with WNT signaling in cancer and discuss potential challenges that may 
      be associated with the chemical attack of this important cellular process in 
      achieving therapeutic goals. Although a number of small molecules targeting WNT 
      signaling are introduced here, we center our discussion on antagonists of the WNT 
      acyltransferase porcupine (PORCN) given the recent entry of two candidate 
      molecules in clinical testing.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Zhang, Li-Shu
AU  - Zhang LS
AD  - University of Texas Southwestern Medical Center, Dallas, TX, United States.
FAU - Lum, Lawrence
AU  - Lum L
AD  - University of Texas Southwestern Medical Center, Dallas, TX, United States. 
      Electronic address: Lawrence.lum@utsouthwestern.edu.
LA  - eng
GR  - R01 CA168761/CA/NCI NIH HHS/United States
GR  - R01 CA196851/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180108
PL  - Netherlands
TA  - Prog Mol Biol Transl Sci
JT  - Progress in molecular biology and translational science
JID - 101498165
RN  - 0 (Membrane Proteins)
RN  - 0 (Pyrazines)
RN  - 0 (Pyridines)
RN  - 0 (Wnt Proteins)
RN  - EC 2.3.- (Acyltransferases)
RN  - EC 2.3.1.- (PORCN protein, human)
RN  - U27F40013Q (LGK974)
SB  - IM
MH  - Acyltransferases/*antagonists & inhibitors
MH  - Humans
MH  - Membrane Proteins/*antagonists & inhibitors
MH  - Neoplasms/*drug therapy/metabolism/pathology
MH  - Pyrazines/*pharmacology
MH  - Pyridines/*pharmacology
MH  - Wnt Proteins/*metabolism
MH  - Wnt Signaling Pathway/*drug effects
OTO - NOTNLM
OT  - APC
OT  - RNF43
OT  - TCF7L2
OT  - WNT
OT  - colorectal cancer
OT  - dysgeusia
OT  - hepatocellular cancer
OT  - immunooncology
OT  - pancreatic cancer
OT  - porcupine
OT  - beta-catenin
EDAT- 2018/02/02 06:00
MHDA- 2019/01/10 06:00
CRDT- 2018/02/02 06:00
PHST- 2018/02/02 06:00 [entrez]
PHST- 2018/02/02 06:00 [pubmed]
PHST- 2019/01/10 06:00 [medline]
AID - S1877-1173(17)30186-2 [pii]
AID - 10.1016/bs.pmbts.2017.11.008 [doi]
PST - ppublish
SO  - Prog Mol Biol Transl Sci. 2018 Jan;153:245-269. doi: 
      10.1016/bs.pmbts.2017.11.008. Epub 2018 Jan 8.