PMID- 2938978 OWN - NLM STAT- MEDLINE DCOM- 19860528 LR - 20190624 IS - 0014-2999 (Print) IS - 0014-2999 (Linking) VI - 121 IP - 2 DP - 1986 Feb 18 TI - Regulatory role of atrial natriuretic polypeptide in water drinking in rats. PG - 285-7 AB - Intracerebroventricular (i.c.v.) administration of synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) decreased the water intake of dehydrated rats. Anti-ANP antiserum, which can neutralize endogenous ANP, potentiated the water intake induced by water deprivation or angiotensin II (AII) injection in rats. These findings suggest that endogenous ANP in rat brain antagonizes the action of AII and plays an important role in the maintenance of drinking behavior. FAU - Katsuura, G AU - Katsuura G FAU - Nakamura, M AU - Nakamura M FAU - Inouye, K AU - Inouye K FAU - Kono, M AU - Kono M FAU - Nakao, K AU - Nakao K FAU - Imura, H AU - Imura H LA - eng PT - Comparative Study PT - Journal Article PL - Netherlands TA - Eur J Pharmacol JT - European journal of pharmacology JID - 1254354 RN - 0 (Immune Sera) RN - 11128-99-7 (Angiotensin II) RN - 85637-73-6 (Atrial Natriuretic Factor) SB - IM MH - Angiotensin II/pharmacology MH - Animals MH - Atrial Natriuretic Factor/administration & dosage/pharmacology/*physiology MH - *Drinking/drug effects MH - Immune Sera/pharmacology MH - Injections, Intraventricular MH - Male MH - Rats MH - Rats, Inbred Strains MH - Time Factors EDAT- 1986/02/18 00:00 MHDA- 1986/02/18 00:01 CRDT- 1986/02/18 00:00 PHST- 1986/02/18 00:00 [pubmed] PHST- 1986/02/18 00:01 [medline] PHST- 1986/02/18 00:00 [entrez] AID - 0014-2999(86)90502-9 [pii] AID - 10.1016/0014-2999(86)90502-9 [doi] PST - ppublish SO - Eur J Pharmacol. 1986 Feb 18;121(2):285-7. doi: 10.1016/0014-2999(86)90502-9.