PMID- 29390417
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - Diabetes mellitus is a risk factor for low bone mass-related fractures: A 
      meta-analysis of cohort studies.
PG  - e8811
LID - 10.1097/MD.0000000000008811 [doi]
LID - e8811
AB  - BACKGROUND: Diabetes mellitus (DM) is inconsistently associated with the risk of 
      low bone mass-related fractures (LBMF). This study aimed to summarize available 
      cohort studies regarding the strength of association between type 2 diabetes 
      mellitus (T2DM) and LBMF. METHODS: Electronic searches of PubMed, Embase, and the 
      Cochrane Library were performed to identify studies through April 2016. Cohort 
      studies that reported effect estimates with 95% confidence intervals (CIs) of 
      LBMF for T2DM and control comparison were included. RESULTS: The summary relative 
      risks (RRs) for T2DM versus non-T2DM were associated with a higher risk of LBMF 
      (RR: 1.24; 95% CI: 1.09-1.41; P = .001). Further, women with T2DM showed a 
      harmful impact on the incidence of LBMF (RR: 1.19; 95% CI: 1.04-1.36; P = .010). 
      However, in men, T2DM showed no significant impact on the risk of LBMF (RR: 1.14; 
      95% CI: 0.93-1.39; P = .215). Furthermore, the summary results suggested an 
      association between T2DM and LBMF in studies that reported hazard ratio (HR) as 
      an effect estimate in total cohorts (HR: 1.31; 95% CI: 1.17-1.46; P < .001), men 
      (HR: 1.26; 95% CI: 1.11-1.43; P < .001), and women (HR: 1.32; 95% CI: 1.16-1.50; 
      P < .001). However, these significant associations were not observed in studies 
      that reported RR/odds ratio as an effect estimate. CONCLUSIONS: The present 
      meta-analysis confirmed that T2DM was associated with an increased prevalence of 
      LBMF compared with non-T2DM.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights 
      reserved.
FAU - Ni, Yu
AU  - Ni Y
AD  - Department of Orthopedics, Beijing Huaxin Hospital, The First Hospital of 
      Tsinghua University Department of Orthopedics, Peking University Third Hospital, 
      Beijing, China.
FAU - Fan, Dongwei
AU  - Fan D
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Body Mass Index
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Osteoporotic Fractures/*epidemiology/etiology
MH  - Prevalence
MH  - Risk Factors
PMC - PMC5758119
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2018/02/03 06:00
MHDA- 2018/02/14 06:00
PMCR- 2017/12/22
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2017/12/22 00:00 [pmc-release]
AID - 00005792-201712220-00004 [pii]
AID - MD-D-16-06894 [pii]
AID - 10.1097/MD.0000000000008811 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e8811. doi: 10.1097/MD.0000000000008811.