PMID- 29390552
OWN - NLM
STAT- MEDLINE
DCOM- 20180214
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 51
DP  - 2017 Dec
TI  - Monocyte chemoattractant protein-1 (MCP-1)-2518 A/G polymorphism and lupus 
      nephritis risk: A PRISMA-compliant meta-analysis.
PG  - e9401
LID - 10.1097/MD.0000000000009401 [doi]
LID - e9401
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) plays an important role in 
      the development of allergic inflammatory reactions by recruiting various immune 
      cells, which is associated with many autoimmune diseases, but the association 
      with the MCP-1-2518A/G gene polymorphism and lupus nephritis (LN) was still 
      controversial in previous studies. Thus, we performed a meta-analysis to derive a 
      more precise evaluation of the association between MCP-1 -2518A/G polymorphism 
      and LN risk and evaluated influence of ethnicity and source of controls. METHODS: 
      A systematic review and meta-analysis that will be performed according to the 
      Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). 
      Relevant literatures dated to September 2016 were acquired from the PubMed, 
      EMBASE, Cochran Library databases. A total of 961 LN cases and 1867 controls were 
      extracted from 10 published case-control studies. We used odds ratios (OR) with 
      95% confidence intervals (CI) to assess the risk of LN with MCP-1-2518A/G. 
      RESULTS: Our meta-analysis suggested that MCP-1-2518A/G polymorphism was 
      associated with the risk of LN (GG vs AG+AA: P < .01, OR = 1.42, 95% CI: 
      1.13-1.79 and A vs G P = .02, OR = 0.74, 95% CI: 0.58-0.95). Then the subgroup 
      analysis showed MCP-1 -2518 A/G gene has a certain correlation with LN 
      susceptibility in the American population (GG vs AA: P < .01, OR = 5.70, 95% CI: 
      2.09-15.50, GG vs AG+AA: P < .01, OR = 3.31, 95% CI: 1.97-5.54, GG+AG vs AA: 
      P < .01, OR = 2.86, 95% CI: 1.14-7.18, and A vs G: P < .01, OR = 0.43, 95% CI: 
      0.24-0.79), while no significant risk in Europeans and Asians. CONCLUSION: The 
      current meta-analysis suggests that the MCP-1-2518A/G polymorphism is associated 
      with an increased risk of LN, especially in the American population. However, 
      better-designed studies with larger sample sizes are needed to validate the 
      results.
CI  - Copyright (c) 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights 
      reserved.
FAU - Sang, Guo-Yao
AU  - Sang GY
AD  - Laboratory Medicine Diagnostic Centre Periodontal and mucosal department, The 
      First Affiliated Hospital Department of Epidemiology and biostatistics, School of 
      Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China.
FAU - Meng, Cun-Ren
AU  - Meng CR
FAU - Hao, Yun-Fei
AU  - Hao YF
FAU - Dai, Jiang-Hong
AU  - Dai JH
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Lupus Nephritis/ethnology/*genetics
MH  - Models, Statistical
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
PMC - PMC5758254
COIS- The authors have no financial conflicts of interest.
EDAT- 2018/02/03 06:00
MHDA- 2018/02/15 06:00
PMCR- 2017/12/22
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/02/15 06:00 [medline]
PHST- 2017/12/22 00:00 [pmc-release]
AID - 00005792-201712220-00139 [pii]
AID - MD-D-17-05630 [pii]
AID - 10.1097/MD.0000000000009401 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Dec;96(51):e9401. doi: 10.1097/MD.0000000000009401.