PMID- 29390957
OWN - NLM
STAT- MEDLINE
DCOM- 20180613
LR  - 20181113
IS  - 1471-2431 (Electronic)
IS  - 1471-2431 (Linking)
VI  - 18
IP  - 1
DP  - 2018 Feb 1
TI  - Streptococcus agalactiae meningoencephalitis associated with gastroesophageal 
      reflux disease and chronic proton pump inhibitors use, in a 9 month-old infant: a 
      case report.
PG  - 21
LID - 10.1186/s12887-018-0995-0 [doi]
LID - 21
AB  - BACKGROUND: Streptococcus agalactiae (Group B Streptococcus) is recognized as the 
      etiologic agent of newborn and infant meningitis, aged up to 90 days, starting 
      from the colonization of the maternal genital or gastrointestinal tract, but it 
      is rarely responsible for meningitis in old infants. CASE PRESENTATION: We 
      present the case of a 9 month-old infant diagnosed with S. agalactiae 
      meningoencephalitis associated with chronic gastroesophageal reflux disease 
      treated with a proton pump inhibitor (PPI). CONCLUSION: The use of a PPI is a 
      risk factor for ultra-late onset of Group B Streptococcus meningitis. The use of 
      PPI in infants should be closely monitored in the light of changes in the gut 
      microbiota, in the oropharyngeal and of the respiratory tract colonization, 
      potentially with pathogenic flora.
FAU - Birlutiu, Victoria
AU  - Birlutiu V
AD  - Lucian Blaga University of Sibiu, Faculty of Medicine; Infectious Diseases 
      Clinic, Academic Emergency Hospital Sibiu, Alba-Iulia Str. No.79 23/8, 550052, 
      Sibiu, Romania. victoriabirlutiu@yahoo.com.
FAU - Luca, Codruta Mihaela
AU  - Luca CM
AD  - Pediatric Infectious Diseases Clinic, Clinical Pediatric Hospital, Sibiu, 
      Romania.
FAU - Birlutiu, Rares-Mircea
AU  - Birlutiu RM
AD  - Lucian Blaga University of Sibiu, Faculty of Medicine; "FOISOR" Clinical Hospital 
      of Orthopedics, Traumatology and Osteoarticular TB Bucharest, Sibiu, Romania.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180201
PL  - England
TA  - BMC Pediatr
JT  - BMC pediatrics
JID - 100967804
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Gastroesophageal Reflux/*complications/drug therapy/microbiology
MH  - Gastrointestinal Microbiome/drug effects
MH  - Humans
MH  - Infant
MH  - Leukopenia/chemically induced
MH  - Male
MH  - Meningoencephalitis/*complications/diagnostic imaging/microbiology
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Streptococcal Infections/*complications
MH  - *Streptococcus agalactiae
PMC - PMC5796439
OTO - NOTNLM
OT  - Gastroesophageal reflux disease
OT  - Infant
OT  - Meningoencephalitis
OT  - Proton pump inhibitors
OT  - Streptococcus agalactiae
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable. CONSENT FOR 
      PUBLICATION: Written informed consent was obtained from the patient's parents for 
      publication of this case report and any accompanying images. COMPETING INTERESTS: 
      The authors declare that they have no competing interests. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2018/02/03 06:00
MHDA- 2018/06/14 06:00
PMCR- 2018/02/01
CRDT- 2018/02/03 06:00
PHST- 2016/11/24 00:00 [received]
PHST- 2018/01/18 00:00 [accepted]
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/06/14 06:00 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1186/s12887-018-0995-0 [pii]
AID - 995 [pii]
AID - 10.1186/s12887-018-0995-0 [doi]
PST - epublish
SO  - BMC Pediatr. 2018 Feb 1;18(1):21. doi: 10.1186/s12887-018-0995-0.