PMID- 29391909 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200929 IS - 1869-3474 (Print) IS - 1869-3482 (Electronic) IS - 1869-3474 (Linking) VI - 52 IP - 1 DP - 2018 Feb TI - Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies. PG - 24-30 LID - 10.1007/s13139-017-0484-7 [doi] AB - The pathological features of Alzheimer's disease are senile plaques which are aggregates of beta-amyloid peptides and neurofibrillary tangles in the brain. Neurofibrillary tangles are aggregates of hyperphosphorylated tau proteins, and these induce various other neurodegenerative diseases, such as progressive supranuclear palsy, corticobasal degeneration, frontotemporal lobar degeneration, frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and chronic traumatic encephalopathy. In the case of Alzheimer's disease, the measurement of neurofibrillary tangles associated with cognitive decline is suitable for differential diagnosis, disease progression assessment, and to monitor the effects of therapeutic treatment. This review discusses considerations for the development of tau ligands for imaging and summarizes the results of the first-in-human and preclinical studies of the tau tracers that have been developed thus far. The development of tau ligands for imaging studies will be helpful for differential diagnosis and for the development of therapeutic treatments for tauopathies including Alzheimer's disease. FAU - Choi, Yoori AU - Choi Y AD - 1Department of Nuclear Medicine, College of Medicine, Seoul National University, 110-744, 28 Yongon-Dong, Jongno-Gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 AD - 2Department of Nuclear Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744 South Korea. ISNI: 0000 0001 0302 820X. GRID: grid.412484.f FAU - Ha, Seunggyun AU - Ha S AD - 1Department of Nuclear Medicine, College of Medicine, Seoul National University, 110-744, 28 Yongon-Dong, Jongno-Gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 AD - 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, 03080, 103 Daehak-ro, Jongno-gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 FAU - Lee, Yun-Sang AU - Lee YS AD - 1Department of Nuclear Medicine, College of Medicine, Seoul National University, 110-744, 28 Yongon-Dong, Jongno-Gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 AD - 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, 03080, 103 Daehak-ro, Jongno-gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 FAU - Kim, Yun Kyung AU - Kim YK AD - 4Institute of Brain Science, Korean Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791 South Korea. ISNI: 0000000121053345. GRID: grid.35541.36 FAU - Lee, Dong Soo AU - Lee DS AD - 1Department of Nuclear Medicine, College of Medicine, Seoul National University, 110-744, 28 Yongon-Dong, Jongno-Gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 AD - 2Department of Nuclear Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744 South Korea. ISNI: 0000 0001 0302 820X. GRID: grid.412484.f AD - 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, 03080, 103 Daehak-ro, Jongno-gu, Seoul, South Korea. ISNI: 0000 0004 0470 5905. GRID: grid.31501.36 FAU - Kim, Dong Jin AU - Kim DJ AD - 4Institute of Brain Science, Korean Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul, 136-791 South Korea. ISNI: 0000000121053345. GRID: grid.35541.36 LA - eng PT - Journal Article PT - Review DEP - 20170607 PL - Germany TA - Nucl Med Mol Imaging JT - Nuclear medicine and molecular imaging JID - 101530478 PMC - PMC5777957 OTO - NOTNLM OT - Alzheimer's disease OT - Imaging ligands OT - Pet OT - Radiopharmaceutical OT - Tau OT - Tauopathy COIS- Compliance with Ethical StandardsAuthors Yoori Choi, Seunggyun Ha, Yun-Sang Lee, and Yun Kyung Kim declare that they have no conflict of interest. Author Dong Soo Lee has received research grants from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C0466), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3344), and funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1277). Author Dong Jin Kim has received a research grant supported by the Brain Research Program through the National Research Foundation of Korea (NRF-2016M3C7A1913845).All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.For this type of study formal consent is not required. EDAT- 2018/02/03 06:00 MHDA- 2018/02/03 06:01 PMCR- 2019/02/01 CRDT- 2018/02/03 06:00 PHST- 2017/02/16 00:00 [received] PHST- 2017/05/10 00:00 [revised] PHST- 2017/05/22 00:00 [accepted] PHST- 2018/02/03 06:00 [entrez] PHST- 2018/02/03 06:00 [pubmed] PHST- 2018/02/03 06:01 [medline] PHST- 2019/02/01 00:00 [pmc-release] AID - 484 [pii] AID - 10.1007/s13139-017-0484-7 [doi] PST - ppublish SO - Nucl Med Mol Imaging. 2018 Feb;52(1):24-30. doi: 10.1007/s13139-017-0484-7. Epub 2017 Jun 7.