PMID- 29391997
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2667-7466 (Print)
IS  - 2149-553X (Electronic)
IS  - 2667-7466 (Linking)
VI  - 53
IP  - 4
DP  - 2015 Dec
TI  - The Relationship between Th1/Th2 Balance and 1alpha, 25-Dihydroxyvitamin D(3) in 
      Patients with Allergic Rhinitis.
PG  - 139-143
LID - 10.5152/tao.2015.1187 [doi]
AB  - OBJECTIVE: With regard to the correlation between T helper1/T helper2 (Th1/Th2) 
      cell balance and 1alpha,25-dihydroxyvitamin D(3), active metabolite of vitamin D, we 
      studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin 
      (IL)-4, IL-10 and interferon-gamma (IFN-gamma), which are important for immune 
      response of patients with allergic rhinitis. METHODS: Thirty adult patients 
      diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control 
      group) are examined in the research. IFN-gamma, IL-4, IL-10, and total immunoglobulin 
      E (IgE) levels from serum samples and vitamin D(3) levels from plasma were 
      determined in all patients. RESULTS: In IgE, IL-4, IL-10, IFN-gamma, and 
      1alpha,25-dihydroxyvitamin D(3) levels (p<0.05), a statistically noticeable 
      difference was observed between the study and control group. The 
      1alpha,25-dihydroxyvitamin D(3) levels in both groups were compared and a 
      statistically significant difference between the 1alpha,25-dihydroxyvitamin D(3) 
      levels in the study group and that in the control group (p<0.05) was observed. 
      There was a positive correlation between IFN-gamma and vitamin D levels (p<0.05) in 
      the study group, whereas IgE, IL-4, and IL-10 levels showed a negative 
      correlation with vitamin D(3) levels (p<0.05). CONCLUSION: In our study, 
      1alpha,25-dihydroxyvitamin D(3) levels were associated with Th1/Th2 balance in 
      allergic rhinitis, and a remarkable correlation was observed among vitamin D 
      deficiency and allergy. These findings show that 1alpha,25-dihydroxyvitamin D(3) may 
      have a remarkable role in the severity and control of allergic disorders. In 
      addition, further investigations are required to confirm how vitamin D should be 
      used in allergic diseases. Furthermore, to reveal the exact mechanism of vitamin 
      D on allergic diseases, further studies are required.
FAU - Keles, Erol
AU  - Keles E
AD  - Department of Otorhinoloryngolojy, Firat Universty School of Medicine, Elazig, 
      Turkey.
FAU - Ozkara, Sule
AU  - Ozkara S
AD  - Department of Otorhinoloryngolojy, Firat Universty School of Medicine, Elazig, 
      Turkey.
FAU - Ilhan, Nevin
AU  - Ilhan N
AD  - Department of Biochemistry, Firat Universty School of Medicine, Elazig, Turkey.
FAU - Gungor, Hilal
AU  - Gungor H
AD  - Department of Biochemistry, Firat Universty School of Medicine, Elazig, Turkey.
FAU - Karlidag, Turgut
AU  - Karlidag T
AD  - Department of Otorhinoloryngolojy, Firat Universty School of Medicine, Elazig, 
      Turkey.
FAU - Yalcin, Sinasi
AU  - Yalcin S
AD  - Department of Otorhinoloryngolojy, Firat Universty School of Medicine, Elazig, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20151201
PL  - Turkey
TA  - Turk Arch Otorhinolaryngol
JT  - Turkish archives of otorhinolaryngology
JID - 101682806
PMC - PMC5782977
OTO - NOTNLM
OT  - Rhinitis
OT  - Th1 cells
OT  - Th2 cells
OT  - allergic
OT  - cholecalciferol
OT  - interferon-gamma
OT  - interleukin-10
OT  - interleukin-4
COIS- Conflict of Interest: No conflict of interest was declared by the authors.
EDAT- 2015/12/01 00:00
MHDA- 2015/12/01 00:01
PMCR- 2015/12/01
CRDT- 2018/02/03 06:00
PHST- 2015/10/19 00:00 [received]
PHST- 2016/01/09 00:00 [accepted]
PHST- 2018/02/03 06:00 [entrez]
PHST- 2015/12/01 00:00 [pubmed]
PHST- 2015/12/01 00:01 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - tao-53-4-139 [pii]
AID - 10.5152/tao.2015.1187 [doi]
PST - ppublish
SO  - Turk Arch Otorhinolaryngol. 2015 Dec;53(4):139-143. doi: 10.5152/tao.2015.1187. 
      Epub 2015 Dec 1.