PMID- 29392317
OWN - NLM
STAT- MEDLINE
DCOM- 20180806
LR  - 20180806
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 2
DP  - 2018 Feb 1
TI  - Association Between Soluble CD14 in the Aqueous Humor and Hyperreflective Foci on 
      Optical Coherence Tomography in Patients With Diabetic Macular Edema.
PG  - 715-721
LID - 10.1167/iovs.17-23042 [doi]
AB  - PURPOSE: To investigate the associations between soluble CD14 (sCD14), a cytokine 
      released by microglia and macrophages, and hyperreflective foci (HF) and various 
      characteristics of spectral-domain optical coherence tomography (SD-OCT) in 
      diabetic macular edema (DME). METHODS: Sixty-nine eyes from 51 patients with DME 
      and 28 eyes from 28 control subjects were studied. sCD14 levels in the aqueous 
      humor (AH) were measured using ELISA before bevacizumab injection (IVB), and the 
      associations between sCD14 and visual acuity, the number of HF, retinal volume, 
      and the DME pattern were assessed. RESULTS: sCD14 levels were higher in DME 
      patients than in the control subjects (29.9 +/- 41.6 pg/mL versus 8.1 +/- 3.6 pg/mL, 
      P < 0.001). sCD14 levels in diffuse edema were higher than those in focal edema 
      (50.0 +/- 65.3 pg/mL versus 19.8 +/- 14.7 pg/mL, P = 0.039). The number of HF in the 
      inner retina of patients with diffuse edema was significantly higher than that in 
      patients with focal edema (4.4 +/- 2.3 vs. 2.6 +/- 2.1, P = 0.001), but no difference 
      was found in the outer retina (5.8 +/- 3.4 vs. 5.0 +/- 3.9, P = 0.25). According to 
      multivariate analyses, elevated sCD14 levels were associated with an increased 
      inner nuclear layer volume and the total number of HF in all retinal layers on 
      SD-OCT. Reduction of DME following IVB was correlated with reduction in the 
      number of HF in a subset of eyes followed longitudinally in the study (n = 30). 
      CONCLUSIONS: DME patients with diffuse edema exhibit higher sCD14 levels in the 
      AH and more HF in the inner retina than patients with focal edema, indicating 
      severe inflammation. The strong correlation between sCD14 and HF in the inner 
      retina suggests that the HF observed on SD-OCT may be due to activated microglia 
      in DME.
FAU - Lee, Hyungwoo
AU  - Lee H
AD  - Department of Ophthalmology, Konkuk University School of Medicine, Konkuk 
      University Medical Center, Seoul, Republic of Korea.
FAU - Jang, Hyoik
AU  - Jang H
AD  - Department of Ophthalmology, Konkuk University School of Medicine, Konkuk 
      University Medical Center, Seoul, Republic of Korea.
FAU - Choi, Youn A
AU  - Choi YA
AD  - Department of Ophthalmology, Konkuk University School of Medicine, Konkuk 
      University Medical Center, Seoul, Republic of Korea.
FAU - Kim, Hyung Chan
AU  - Kim HC
AD  - Department of Ophthalmology, Konkuk University School of Medicine, Konkuk 
      University Medical Center, Seoul, Republic of Korea.
FAU - Chung, Hyewon
AU  - Chung H
AD  - Department of Ophthalmology, Konkuk University School of Medicine, Konkuk 
      University Medical Center, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
RN  - 0 (Angiogenesis Inhibitors)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 2S9ZZM9Q9V (Bevacizumab)
SB  - IM
CIN - Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5366. PMID: 30452588
CIN - Invest Ophthalmol Vis Sci. 2018 Nov 1;59(13):5367. PMID: 30452589
MH  - Adult
MH  - Aged
MH  - Angiogenesis Inhibitors/therapeutic use
MH  - Aqueous Humor/*metabolism
MH  - Bevacizumab/therapeutic use
MH  - Diabetic Retinopathy/diagnostic imaging/drug therapy/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intravitreal Injections
MH  - Lipopolysaccharide Receptors/*metabolism
MH  - Macular Edema/diagnostic imaging/drug therapy/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Retina/*diagnostic imaging
MH  - Tomography, Optical Coherence
MH  - Vascular Endothelial Growth Factor A/antagonists & inhibitors
EDAT- 2018/02/03 06:00
MHDA- 2018/08/07 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [entrez]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/08/07 06:00 [medline]
AID - 2671880 [pii]
AID - 10.1167/iovs.17-23042 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):715-721. doi: 10.1167/iovs.17-23042.