PMID- 29392750
OWN - NLM
STAT- MEDLINE
DCOM- 20191125
LR  - 20191210
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 96
IP  - 6
DP  - 2018 Jun
TI  - Nasal obstruction during adolescence induces memory/learning impairments 
      associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone 
      levels.
PG  - 1056-1065
LID - 10.1002/jnr.24216 [doi]
AB  - The hippocampus is an important brain region involved in memory and learning. 
      Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and 
      phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute 
      to hippocampal memory/learning. The present study aimed to clarify the effects of 
      nasal obstruction during the growth period on memory/learning in an animal model, 
      using combined behavioral, biochemical, and histological approaches. Male BALB/C 
      mice underwent unilateral nasal obstruction (UNO) by cauterization at 8 days of 
      age and were subjected to Y-maze and passive avoidance tests at 15 weeks of age. 
      The serum corticosterone levels were measured using an enzyme-linked 
      immunosorbent assay, and brain tissues were subjected to hematoxylin-eosin 
      staining and histological analysis or homogenization and Western blot analysis. 
      Compared with control mice, UNO mice had lower blood oxygen saturation levels and 
      exhibited apparent memory/learning impairments during behavioral testing. 
      Additionally, the UNO group had higher hippocampal BDNF levels and serum 
      corticosterone levels, lower hippocampal TrkB and phospho-p44/p42 MAPK levels, 
      and reduced neuron numbers relative to controls. Our findings suggest that UNO 
      during adolescence affects the hippocampus and causes memory/learning 
      impairments.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Ogawa, Takuya
AU  - Ogawa T
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Okihara, Hidemasa
AU  - Okihara H
AUID- ORCID: 0000-0002-3762-2597
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Kokai, Satoshi
AU  - Kokai S
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Abe, Yasunori
AU  - Abe Y
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Karin Harumi, Uchima Koecklin
AU  - Karin Harumi UK
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Makiguchi, Mio
AU  - Makiguchi M
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Kato, Chiho
AU  - Kato C
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Yabushita, Tadachika
AU  - Yabushita T
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
FAU - Michikawa, Makoto
AU  - Michikawa M
AD  - Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City 
      University, Nagoya, Japan.
FAU - Ono, Takashi
AU  - Ono T
AD  - Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180202
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Avoidance Learning
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/*blood
MH  - Hippocampus/*metabolism/pathology
MH  - Learning Disabilities/*metabolism/pathology
MH  - Male
MH  - Maze Learning
MH  - Membrane Glycoproteins/*metabolism
MH  - Memory/*physiology
MH  - Memory Disorders/*metabolism/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Nasal Obstruction/blood/*metabolism/pathology/psychology
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - Random Allocation
MH  - Signal Transduction
OTO - NOTNLM
OT  - BDNF
OT  - SpO2
OT  - corticosterone
OT  - hippocampus
OT  - memory/learning impairment
EDAT- 2018/02/03 06:00
MHDA- 2019/11/26 06:00
CRDT- 2018/02/03 06:00
PHST- 2017/09/08 00:00 [received]
PHST- 2017/12/28 00:00 [revised]
PHST- 2018/01/02 00:00 [accepted]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2019/11/26 06:00 [medline]
PHST- 2018/02/03 06:00 [entrez]
AID - 10.1002/jnr.24216 [doi]
PST - ppublish
SO  - J Neurosci Res. 2018 Jun;96(6):1056-1065. doi: 10.1002/jnr.24216. Epub 2018 Feb 
      2.