PMID- 29393842
OWN - NLM
STAT- MEDLINE
DCOM- 20181002
LR  - 20190318
IS  - 0301-0430 (Print)
IS  - 0301-0430 (Linking)
VI  - 90
IP  - 1
DP  - 2018 Jul
TI  - A study of urinary Tamm-Horsfall protein excretion in adult type 2 diabetes 
      mellitus
.
PG  - 40-45
LID - 10.5414/CN109220 [doi]
AB  - AIM: To study the excretion of urinary Tamm-Horsfall protein (THP) with a wide 
      range of urinary albumin creatinine ratio (UACR) and estimated glomerular 
      filtration rate (eGFR) in a population with type 2 diabetes mellitus (T2DM). 
      MATERIALS AND METHODS: A retrospective investigation was performed in 3,599 adult 
      inpatients with T2DM in Anhui Provincial Hospital of China. Demographic 
      information, urinary THP data, and other lab reports were obtained from the 
      Electronic Patient Record (EPR). RESULTS: (1) In T2DM, average HbA1c was 8.6%, 
      and 55.2% of the patients had an HbA1c > 9%. The percentages with normal 
      excretion, decreased excretion, and increased excretion of urinary THP were 
      49.8%, 41.7%, and 8.5%, respectively. Serum creatinine (Scr), blood urea nitrogen 
      (BUN), and UACR levels were highest, and eGFR was lowest, in the decreased 
      urinary THP group. (2) The proportion of decreased urinary THP excretion rose, 
      and the level of urinary THP declined when UACR increased or eGFR decreased. (3) 
      Urinary THP showed a negative correlation to Scr, BUN, triglyceride (TG), and 
      UACR (rs = -0.173, -0.228, -0.060 and -0.237, respectively), but a positive 
      correlation with eGFR and high-density lipoprotein cholesterol (HDL-C) (rs =0.128 
      and 0.040, respectively). (4) Logistical regression analysis showed that Scr, 
      BUN, TG, UACR, and eGFR were independent risk factors for decreased urinary THP 
      (OR = 3.477, 1.461, 1.160, 2.124, and 2.087, respectively). CONCLUSION: Increased 
      albuminuria and decreased GFR are predictors of decreased urinary THP excretion. 
      Distal convoluted tubule lesion may precede glomerular damage in a portion of 
      T2DM patients.
.
FAU - Zheng, Mao
AU  - Zheng M
FAU - Ye, Shandong
AU  - Ye S
FAU - Chen, Yan
AU  - Chen Y
FAU - Chen, Meinan
AU  - Chen M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Nephrol
JT  - Clinical nephrology
JID - 0364441
RN  - 0 (Uromodulin)
SB  - IM
MH  - Adult
MH  - Albuminuria
MH  - Diabetes Mellitus, Type 2/*epidemiology/*urine
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Uromodulin/*urine
EDAT- 2018/02/03 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/06/13 00:00 [accepted]
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/02/03 06:00 [entrez]
AID - 16593 [pii]
AID - 10.5414/CN109220 [doi]
PST - ppublish
SO  - Clin Nephrol. 2018 Jul;90(1):40-45. doi: 10.5414/CN109220.