PMID- 29394168
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20211204
IS  - 1532-0979 (Electronic)
IS  - 0147-5185 (Linking)
VI  - 42
IP  - 5
DP  - 2018 May
TI  - Low-grade Endometrioid Stromal Sarcoma of the Paratestis: A Novel Report With 
      Molecular Confirmation of JAZF1/SUZ12 Translocation.
PG  - 695-700
LID - 10.1097/PAS.0000000000001030 [doi]
AB  - Tumors with Mullerian-like serous or mucinous phenotypes originating in the 
      testis and its adnexa are rare neoplasms that have been increasingly recognized 
      in recent years. Cystadenomas with or without ovarian-type stroma, borderline 
      tumors, and adenocarcinomas are the main documented types. Although a handful 
      cases of putative endometrioid adenocarcinomas have been reported, to our 
      knowledge no case of endometrial stromal-type neoplasm has ever been reported in 
      the literature. A 59-year-old man presented with a 2 cm left intrascrotal mass 
      that was found on sonographic examination to arise from the epididymal tail with 
      prominent vascularization. He was otherwise healthy without significant clinical 
      history, endocrinopathy, or external hormone therapy. His testicular tumor 
      markers (beta-HCG, AFP) were normal. Histologic examination of the resection 
      showed a multinodular tumor closely associated with the epididymis and composed 
      of monotonous rounded to ovoid cells with scanty cytoplasm and prominent 
      spiral-like arterioles and capillaries. Mitotic activity was high. No other tumor 
      component was seen. Immunohistochemistry revealed strong and diffuse expression 
      of vimentin, CD10, estrogen receptor, and progesterone receptor. Molecular 
      examination (performed on paraffin-embedded tumor tissue using a 517 gene fusion 
      next-generation sequencing assay) showed a JAZF1/SUZ12 translocation, which was 
      then confirmed by fluorescence in situ hybridization (FISH). These findings are 
      consistent with a low-grade endometrioid stromal sarcoma originating in the 
      paratestis. This report represents a novel addition to the growing spectrum of 
      Mullerian-analog testicular adnexal neoplasms.
FAU - Agaimy, Abbas
AU  - Agaimy A
AD  - Institute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, 
      University Hospital of Erlangen, Erlangen.
FAU - Moskalev, Evgeny A
AU  - Moskalev EA
AD  - Institute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, 
      University Hospital of Erlangen, Erlangen.
FAU - Weisser, Wera
AU  - Weisser W
AD  - Institute for Hematopathology.
FAU - Bach, Thorsten
AU  - Bach T
AD  - Department of Urology, Asklepios Clinic Harburg, Hamburg, Germany.
FAU - Haller, Florian
AU  - Haller F
AD  - Institute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, 
      University Hospital of Erlangen, Erlangen.
FAU - Hartmann, Arndt
AU  - Hartmann A
AD  - Institute of Pathology, Friedrich-Alexander University of Erlangen-Nuremberg, 
      University Hospital of Erlangen, Erlangen.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Co-Repressor Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (JAZF1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (SUZ12 protein, human)
RN  - 0 (Transcription Factors)
RN  - EC 2.1.1.43 (Polycomb Repressive Complex 2)
SB  - IM
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Co-Repressor Proteins
MH  - DNA-Binding Proteins
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Proteins/*genetics
MH  - Phenotype
MH  - Polycomb Repressive Complex 2/*genetics
MH  - Sarcoma, Endometrial Stromal/chemistry/*genetics/pathology/surgery
MH  - Testicular Neoplasms/chemistry/*genetics/pathology/surgery
MH  - Transcription Factors
MH  - Translocation, Genetic
EDAT- 2018/02/03 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2018/02/03 06:00 [entrez]
AID - 10.1097/PAS.0000000000001030 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 2018 May;42(5):695-700. doi: 10.1097/PAS.0000000000001030.