PMID- 29394488
OWN - NLM
STAT- MEDLINE
DCOM- 20181224
LR  - 20181224
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 43
IP  - 7
DP  - 2018 Jul
TI  - Effect of 7 days of exercise on exogenous carbohydrate oxidation and insulin 
      resistance in children with obesity.
PG  - 677-683
LID - 10.1139/apnm-2017-0358 [doi]
AB  - The capacity to match carbohydrate (CHO) oxidation with CHO availability (deemed 
      metabolic flexibility (MetFlex)) may be important for type 2 diabetes prevention. 
      In adults, impaired MetFlex is associated with insulin resistance (IR), which can 
      be improved with as little as 7 days of exercise. Whether this occurs similarly 
      in children is unknown. We hypothesized that 7 consecutive days of exercise would 
      improve MetFlex and IR in children with obesity. Twelve children (8 boys, 4 
      girls) completed 2 study visits before (PRE) and 2 study visits after (POST) 
      exercise training. At visit 1, fasting blood was collected, and anthropometry and 
      maximal oxygen uptake were assessed. At visit 2, a (13)C-enriched CHO drink was 
      ingested before exercise (3 x 20 min) at  approximately 59% maximal oxygen uptake. Exogenous 
      CHO oxidative efficiency, used as a surrogate measurement of MetFlex, was 
      calculated from breath samples. During training, participants alternated between 
      continuous and high-intensity interval cycling sessions at home under 
      supervision. In spite of good training adherence, there was no improvement in 
      MetFlex (PRE: 20.7% +/- 1.8%, POST: 18.9% +/- 4.9%, p = 0.22) or homeostasis model 
      assessment of insulin resistance (PRE: 8.7 +/- 4.6, POST: 8.1 +/- 6.0, p = 0.51). 
      Future research should investigate exercise volume, sex, and pubertal effects on 
      the early responsiveness of MetFlex to exercise therapy.
FAU - Chu, Lisa
AU  - Chu L
AD  - a Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON L8S 4K1, Canada.
FAU - Morrison, Katherine M
AU  - Morrison KM
AD  - b Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.
FAU - Riddell, Michael C
AU  - Riddell MC
AD  - c School of Kinesiology & Health Science, Muscle Health Research Centre, York 
      University, Toronto, ON M3J 1P3, Canada.
FAU - Raha, Sandeep
AU  - Raha S
AD  - b Department of Pediatrics, McMaster University, Hamilton, ON L8S 4K1, Canada.
FAU - Timmons, Brian W
AU  - Timmons BW
AD  - a Child Health and Exercise Medicine Program, Department of Pediatrics, McMaster 
      University, Hamilton, ON L8S 4K1, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180202
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/metabolism
MH  - Body Composition
MH  - Body Weight
MH  - Child
MH  - Dietary Carbohydrates/*metabolism
MH  - *Exercise
MH  - Female
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Male
MH  - Patient Compliance
MH  - Pediatric Obesity/blood/*therapy
MH  - Pilot Projects
MH  - Sample Size
OTO - NOTNLM
OT  - children
OT  - enfants
OT  - entrainement physique
OT  - exercise training
OT  - flexibilite metabolique
OT  - insulin resistance
OT  - insulinoresistance
OT  - metabolic flexibility
OT  - obesity
OT  - obesite
EDAT- 2018/02/03 06:00
MHDA- 2018/12/26 06:00
CRDT- 2018/02/03 06:00
PHST- 2018/02/03 06:00 [pubmed]
PHST- 2018/12/26 06:00 [medline]
PHST- 2018/02/03 06:00 [entrez]
AID - 10.1139/apnm-2017-0358 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2018 Jul;43(7):677-683. doi: 10.1139/apnm-2017-0358. 
      Epub 2018 Feb 2.