PMID- 29395668
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1399-0020 (Electronic)
IS  - 0901-5027 (Linking)
VI  - 47
IP  - 7
DP  - 2018 Jul
TI  - EGFR amplification and expression in oral squamous cell carcinoma in young 
      adults.
PG  - 817-823
LID - S0901-5027(18)30002-X [pii]
LID - 10.1016/j.ijom.2018.01.002 [doi]
AB  - The aim of this study was to investigate epidermal growth factor receptor (EGFR) 
      gene alterations in two groups of patients with oral squamous cell carcinoma 
      (OSCC) (a test group of subjects aged </=40 years and a control group of subjects 
      aged >/=50 years) and to associate the results with EGFR immunostaining, 
      clinicopathological features, and the prognosis. Sixty cases of OSCC were 
      selected (test group, n=21; control group, n=39). The tissue microarray technique 
      was applied to ensure the uniformity of results. Gene amplification was analyzed 
      by fluorescence in situ hybridization (FISH), and immunohistochemical staining 
      for EGFR was analyzed using an automated imaging system. EGFR amplification was 
      higher in the test group than in the control group (P=0.018) and was associated 
      with advanced clinical stage (P=0.013), regardless of age. Patients with EGFR 
      overexpression had worse survival rates, as did patients who had T3-T4 tumours 
      and positive margins. EGFR overexpression has a negative impact on disease 
      progression. Despite the higher amplification of EGFR in young adults, it does 
      not significantly impact the survival rates of affected patients.
CI  - Copyright (c) 2018 International Association of Oral and Maxillofacial Surgeons. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Costa, V
AU  - Costa V
AD  - Department of Biosciences and Oral Diagnosis, Institute of Science and 
      Technology, Sao Paulo State University (Unesp), Sao Jose dos Campos, Brazil.
FAU - Kowalski, L P
AU  - Kowalski LP
AD  - Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - Coutinho-Camillo, C M
AU  - Coutinho-Camillo CM
AD  - International Research Center, A.C. Camargo Cancer Center, Sao Paulo, Brazil; 
      Department of Anatomic Pathology, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
FAU - Begnami, M D
AU  - Begnami MD
AD  - Department of Anatomic Pathology, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
FAU - Calsavara, V F
AU  - Calsavara VF
AD  - Department of Epidemiology and Statistics, A.C. Camargo Cancer Center, Sao Paulo, 
      Brazil.
FAU - Neves, J I
AU  - Neves JI
AD  - Department of Anatomic Pathology, A.C. Camargo Cancer Center, Sao Paulo, Brazil.
FAU - Kaminagakura, E
AU  - Kaminagakura E
AD  - Department of Biosciences and Oral Diagnosis, Institute of Science and 
      Technology, Sao Paulo State University (Unesp), Sao Jose dos Campos, Brazil. 
      Electronic address: estela@fosjc.unesp.br.
LA  - eng
PT  - Journal Article
DEP - 20180201
PL  - Denmark
TA  - Int J Oral Maxillofac Surg
JT  - International journal of oral and maxillofacial surgery
JID - 8605826
RN  - EC 2.7.10.1 (EGFR protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Case-Control Studies
MH  - Child
MH  - Disease Progression
MH  - ErbB Receptors/genetics
MH  - Female
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/*genetics/pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Tissue Array Analysis
OTO - NOTNLM
OT  - EGFR gene
OT  - fluorescence in situ hybridization
OT  - immunohistochemistry
OT  - oral cancer
OT  - prognosis
OT  - squamous cell carcinoma
EDAT- 2018/02/06 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/02/04 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2017/10/11 00:00 [revised]
PHST- 2018/01/03 00:00 [accepted]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/02/04 06:00 [entrez]
AID - S0901-5027(18)30002-X [pii]
AID - 10.1016/j.ijom.2018.01.002 [doi]
PST - ppublish
SO  - Int J Oral Maxillofac Surg. 2018 Jul;47(7):817-823. doi: 
      10.1016/j.ijom.2018.01.002. Epub 2018 Feb 1.