PMID- 29395811
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20181001
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 44
IP  - 2
DP  - 2018 Mar
TI  - Can persistent organic pollutants distinguish between two opposite metabolic 
      phenotypes in lean Koreans?
PG  - 168-171
LID - S1262-3636(18)30001-6 [pii]
LID - 10.1016/j.diabet.2017.12.008 [doi]
AB  - AIMS: This study investigated the association of persistent organic pollutants 
      (POPs), an emerging new risk factor for type 2 diabetes and the metabolic 
      syndrome, with the presence of opposite phenotypes of glucose and lipid 
      metabolism among normal-weight Koreans of similar body composition. METHODS: 
      Fifty subjects, randomly selected from an ongoing community-based cohort study, 
      from two opposite phenotype groups - metabolically unhealthy normal weight 
      (MUHNW) and metabolically healthy normal weight (MHNW) - were matched for waist 
      circumference, visceral fat mass and demographic variables, then compared for 
      serum concentrations of POPs. RESULTS: Most POPs (10 out of 13 compounds) were 
      present in higher serum concentrations in the MUHNW than in the MHNW. In 
      particular, serum concentrations of all compounds of the organochlorine pesticide 
      class were 2.2 to 4.7 times higher in cases than in controls. Compared with the 
      lowest tertile of summary measures of POPs, Odds ratios (95% confidence interval) 
      for the second and third tertiles were 7.4 (1.9-29.4) and 10.4 (2.6-41.2), 
      respectively. Adjusting for possible confounders did not change the results. 
      CONCLUSION: Taken altogether, these findings from the present and previous 
      studies suggest that increased serum POP concentrations may play an important 
      role in the development of unhealthy metabolic phenotypes in lean people.
CI  - Copyright (c) 2018 Elsevier Masson SAS. All rights reserved.
FAU - Ha, K H
AU  - Ha KH
AD  - Department of Endocrinology and Metabolism, Ajou University, School of Medicine, 
      Suwon, Republic of Korea; Cardiovascular and Metabolic Disease Etiology Research 
      Center, Ajou University School of Medicine, Suwon, Republic of Korea.
FAU - Kim, S A
AU  - Kim SA
AD  - Department of Biomedical Science, Kyungpook National University, Daegu, Republic 
      of Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical 
      Science, Kyungpook National University, Daegu, Republic of Korea.
FAU - Lee, Y M
AU  - Lee YM
AD  - Department of Preventive Medicine, School of Medicine, Kyungpook National 
      University, 680, Gukchaebosang-ro Jung-gu, Daegu 41944, Republic of Korea.
FAU - Kim, D J
AU  - Kim DJ
AD  - Department of Endocrinology and Metabolism, Ajou University, School of Medicine, 
      Suwon, Republic of Korea; Cardiovascular and Metabolic Disease Etiology Research 
      Center, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic 
      address: djkim@ajou.ac.kr.
FAU - Lee, D H
AU  - Lee DH
AD  - Department of Biomedical Science, Kyungpook National University, Daegu, Republic 
      of Korea; BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical 
      Science, Kyungpook National University, Daegu, Republic of Korea; Department of 
      Preventive Medicine, School of Medicine, Kyungpook National University, 680, 
      Gukchaebosang-ro Jung-gu, Daegu 41944, Republic of Korea. Electronic address: 
      lee_dh@knu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20180106
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/*epidemiology
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Humans
MH  - Ideal Body Weight/physiology
MH  - Male
MH  - Metabolic Syndrome/*blood/*epidemiology
MH  - Phenotype
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Adipose tissue
OT  - Diabetes
OT  - Dyslipidemia
OT  - Obesity
OT  - Persistent organic pollutants
EDAT- 2018/02/06 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/02/04 06:00
PHST- 2017/09/20 00:00 [received]
PHST- 2017/12/02 00:00 [revised]
PHST- 2017/12/19 00:00 [accepted]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/02/04 06:00 [entrez]
AID - S1262-3636(18)30001-6 [pii]
AID - 10.1016/j.diabet.2017.12.008 [doi]
PST - ppublish
SO  - Diabetes Metab. 2018 Mar;44(2):168-171. doi: 10.1016/j.diabet.2017.12.008. Epub 
      2018 Jan 6.