PMID- 29395871
OWN - NLM
STAT- MEDLINE
DCOM- 20181121
LR  - 20220129
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 261
DP  - 2018 Mar
TI  - Clinically significant personality traits in individuals at high risk of 
      developing psychosis.
PG  - 498-503
LID - S0165-1781(17)30790-4 [pii]
LID - 10.1016/j.psychres.2018.01.027 [doi]
AB  - It is still unclear to what extent personality may influence the development of 
      psychosis. We aimed to explore significant personality traits in individuals at 
      high-risk (HR) for psychosis. Personalities of forty HR individuals and a matched 
      sample of 40 healthy volunteers (HVs) were evaluated with the Millon Multiaxial 
      Inventory (MCMI-III). They were also assessed with the Positive and Negative 
      Symptoms Scale (PANSS), Beck Depression and Anxiety Inventories (BDI-II and BAI), 
      Global Assessment of Functioning (GAF) and Mini-International Neuropsychiatric 
      Interview (MINI 6.0.0). Fisher's exact test was employed to compare frequency of 
      traits. Mann-Whitney U test and logistic regression were used to establish 
      relationships between traits and symptoms, and the effect of age, sex and 
      symptoms on such traits. Most HR individuals (97.5%) had at least one significant 
      trait; 75% had personality disorders, mainly depressive, borderline or 
      schizotypal. Only histrionic and narcissistic traits were more prevalent in HVs. 
      Negative symptoms were related to schizoid and paranoid traits. Depression was 
      more severe with borderline traits. Most HR individuals (67.6%) had more than one 
      DSM-IV Axis I diagnosis, mainly depressive/anxiety disorders. Transition rate was 
      low (5%). Certain personality profiles may not be markers for conversions to 
      psychosis but contribute to high morbidity in HR individuals.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Sevilla-Llewellyn-Jones, Julia
AU  - Sevilla-Llewellyn-Jones J
AD  - CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough 
      NHS Foundation Trust, Block 7, Ida Darwin Site, Fulbourn Hospital, CB21 5EE 
      Cambridge, UK; Department of Mental Health, Hospital Clinico Universitario Virgen 
      de la Victoria, Campus de Teatinos, 29010 Malaga, Spain; Faculty of Psychology, 
      Malaga University, Campus de Teatinos, 29010 Malaga, Spain; Institute of 
      Psychiatry and Mental Health. San Carlos Hospital, Av/ Prof. Martin Lago s/n, 
      28040 Madrid, Spain.
FAU - Camino, Gustavo
AU  - Camino G
AD  - Community Mental Health Team, Coaling Island, Gibraltar GX11 1AA, Gibraltar.
FAU - Russo, Debra A
AU  - Russo DA
AD  - CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough 
      NHS Foundation Trust, Block 7, Ida Darwin Site, Fulbourn Hospital, CB21 5EE 
      Cambridge, UK.
FAU - Painter, Michelle
AU  - Painter M
AD  - CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough 
      NHS Foundation Trust, Block 7, Ida Darwin Site, Fulbourn Hospital, CB21 5EE 
      Cambridge, UK.
FAU - Montejo, Angel L
AU  - Montejo AL
AD  - Department of Psychiatry, University Hospital of Salamanca, IBSAL Neurosciences, 
      University of Salamanca, 37007 Salamanca, Spain.
FAU - Ochoa, Susana
AU  - Ochoa S
AD  - Research Unit of Parc Sanitari Sant Joan de Deu. Institut de Recerca Sant Joan de 
      Deu, CIBERSAM, Carrer Antoni Pujadas 42, 08830 Sant Boi de Llobregat, Barcelona, 
      Spain.
FAU - Jones, Peter B
AU  - Jones PB
AD  - CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough 
      NHS Foundation Trust, Block 7, Ida Darwin Site, Fulbourn Hospital, CB21 5EE 
      Cambridge, UK; Department of Psychiatry, University of Cambridge, Cambridge, 
      Herchel Smith Building, CB2 0SZ Cambridge, UK.
FAU - Perez, Jesus
AU  - Perez J
AD  - CAMEO Early Intervention in Psychosis Service, Cambridgeshire and Peterborough 
      NHS Foundation Trust, Block 7, Ida Darwin Site, Fulbourn Hospital, CB21 5EE 
      Cambridge, UK; Department of Psychiatry, University Hospital of Salamanca, IBSAL 
      Neurosciences, University of Salamanca, 37007 Salamanca, Spain; Department of 
      Psychiatry, University of Cambridge, Cambridge, Herchel Smith Building, CB2 0SZ 
      Cambridge, UK; Norwich Medical School, Faculty of Medicine and Health Sciences, 
      University of East Anglia, NR4 7TJ Norwich, UK. Electronic address: 
      jp440@cam.ac.uk.
LA  - eng
GR  - RP-PG-0606-1335/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180112
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Depression/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Personality
MH  - Personality Disorders/*psychology
MH  - Personality Inventory
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*psychology
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - High-risk
OT  - Personality
OT  - Psychosis
OT  - Schizophrenia
EDAT- 2018/02/06 06:00
MHDA- 2018/11/22 06:00
CRDT- 2018/02/04 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/11/20 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/11/22 06:00 [medline]
PHST- 2018/02/04 06:00 [entrez]
AID - S0165-1781(17)30790-4 [pii]
AID - 10.1016/j.psychres.2018.01.027 [doi]
PST - ppublish
SO  - Psychiatry Res. 2018 Mar;261:498-503. doi: 10.1016/j.psychres.2018.01.027. Epub 
      2018 Jan 12.