PMID- 29397560 OWN - NLM STAT- MEDLINE DCOM- 20190204 LR - 20210109 IS - 1559-1182 (Electronic) IS - 0893-7648 (Linking) VI - 55 IP - 9 DP - 2018 Sep TI - Buttermilk and Krill Oil Phospholipids Improve Hippocampal Insulin Resistance and Synaptic Signaling in Aged Rats. PG - 7285-7296 LID - 10.1007/s12035-018-0934-y [doi] AB - Impaired glucose metabolism and mitochondrial decay greatly increase with age, when cognitive decline becomes rampant. No pharmacological or dietary intervention has proven effective, but proper diet and lifestyle do postpone the onset of neurodegeneration and some nutrients are being investigated. We studied insulin signaling, mitochondrial activity and biogenesis, and synaptic signaling in the hippocampus and cortex following dietary supplementation with bioactive phospholipid concentrates of krill oil (KOC), buttermilk fat globule membranes (BMFC), and a combination of both in aged rats. After 3 months of supplementation, although all groups of animals showed clear signs of peripheral insulin resistance, the combination of KOC and BMFC was able to improve peripheral insulin sensitivity. We also explored brain energy balance. Interestingly, the hippocampus of supplemented rats-mainly when supplemented with BMFC or the combination of KOC and BMFC-showed an increase in intracellular adenosine triphosphate (ATP) levels, whereas no difference was observed in the cerebral cortex. Moreover, we found a significant increase of brain-derived neurotrophic factor (BDNF) in the hippocampus of BMFC+KO animals. In summary, dietary supplementation with KOC and/or BMFC improves peripheral and central insulin resistance, suggesting that their administration could delay the onset of these phenomena. Moreover, n-3 fatty acids (FAs) ingested as phospholipids increase BDNF levels favoring an improvement in energy state within neurons and facilitating both mitochondrial and protein synthesis, which are necessary for synaptic plasticity. Thus, dietary supplementation with n-3 FAs could protect local protein synthesis and energy balance within dendrites, favoring neuronal health and delaying cognitive decline associated to age-related disrepair. FAU - Tome-Carneiro, Joao AU - Tome-Carneiro J AD - Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, 28049, Madrid, Spain. FAU - Carmen Crespo, M AU - Carmen Crespo M AD - Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, 28049, Madrid, Spain. FAU - Burgos-Ramos, Emma AU - Burgos-Ramos E AD - Area de Bioquimica, Universidad de Castilla-La-Mancha, 45071, Toledo, Spain. FAU - Tomas-Zapico, Cristina AU - Tomas-Zapico C AD - Department of Functional Biology (Physiology), University of Oviedo, 33006, Oviedo, Spain. AD - Universidad Autonoma de Chile, 7500912, Santiago, Chile. FAU - Garcia-Serrano, Alba AU - Garcia-Serrano A AD - Institute of Food Science Research, Spanish National Research Council (CIAL, CSIC-UAM), Bioactivity and Food Analysis Department, Food Lipid Biomarkers and Health, Campus of Autonoma University of Madrid, 28049, Madrid, Spain. FAU - Castro-Gomez, Pilar AU - Castro-Gomez P AD - Institute of Food Science Research, Spanish National Research Council (CIAL, CSIC-UAM), Bioactivity and Food Analysis Department, Food Lipid Biomarkers and Health, Campus of Autonoma University of Madrid, 28049, Madrid, Spain. FAU - Venero, Cesar AU - Venero C AD - Department of Psychobiology, Faculty of Psychology, UNED, 28040, Madrid, Spain. FAU - Pereda-Perez, Inmaculada AU - Pereda-Perez I AD - Department of Psychobiology, Faculty of Psychology, UNED, 28040, Madrid, Spain. AD - Faculty of Biosanitary Sciences, Francisco de Vitoria University, Pozuelo de Alarcon, 28223, Madrid, Spain. FAU - Baliyan, Shishir AU - Baliyan S AD - Department of Psychobiology, Faculty of Psychology, UNED, 28040, Madrid, Spain. FAU - Valencia, Azucena AU - Valencia A AD - Department of Psychobiology, Faculty of Psychology, UNED, 28040, Madrid, Spain. FAU - Fontecha, Javier AU - Fontecha J AD - Institute of Food Science Research, Spanish National Research Council (CIAL, CSIC-UAM), Bioactivity and Food Analysis Department, Food Lipid Biomarkers and Health, Campus of Autonoma University of Madrid, 28049, Madrid, Spain. FAU - Davalos, Alberto AU - Davalos A AD - Laboratory of Epigenetics of Lipid Metabolism, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, 28049, Madrid, Spain. alberto.davalos@imdea.org. FAU - Visioli, Francesco AU - Visioli F AUID- ORCID: 0000-0002-1756-1723 AD - Laboratory of Functional Foods, Madrid Institute for Advanced Studies (IMDEA)-Food, CEI UAM + CSIC, 28049, Madrid, Spain. AD - Department of Molecular Medicine, University of Padova, 35121, Padova, Italy. LA - eng GR - AGL2014-56464-R1/MICINN/ PT - Journal Article DEP - 20180203 PL - United States TA - Mol Neurobiol JT - Molecular neurobiology JID - 8900963 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Fish Oils) RN - 0 (Insulin) RN - 0 (Phospholipids) SB - IM MH - Aging/*metabolism MH - Animals MH - Brain-Derived Neurotrophic Factor/metabolism MH - *Buttermilk MH - Diet MH - Energy Metabolism/drug effects MH - Euphausiacea MH - Fish Oils/*chemistry MH - Hippocampus/*pathology MH - Insulin/metabolism MH - *Insulin Resistance MH - Male MH - Organelle Biogenesis MH - Phospholipids/*pharmacology MH - Rats, Wistar MH - *Signal Transduction/drug effects MH - Synapses/drug effects/*metabolism OTO - NOTNLM OT - Buttermilk OT - Hippocampus OT - Insulin OT - Krill oil OT - Phospholipids EDAT- 2018/02/06 06:00 MHDA- 2019/02/05 06:00 CRDT- 2018/02/05 06:00 PHST- 2017/10/11 00:00 [received] PHST- 2018/01/25 00:00 [accepted] PHST- 2018/02/06 06:00 [pubmed] PHST- 2019/02/05 06:00 [medline] PHST- 2018/02/05 06:00 [entrez] AID - 10.1007/s12035-018-0934-y [pii] AID - 10.1007/s12035-018-0934-y [doi] PST - ppublish SO - Mol Neurobiol. 2018 Sep;55(9):7285-7296. doi: 10.1007/s12035-018-0934-y. Epub 2018 Feb 3.