PMID- 29398652
OWN - NLM
STAT- MEDLINE
DCOM- 20190121
LR  - 20220321
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 126
IP  - 2
DP  - 2018 Feb 2
TI  - Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male 
      Children: Results from the EDEN Mother-Child Cohort Study.
PG  - 027002
LID - 10.1289/EHP1829 [doi]
LID - 027002
AB  - BACKGROUND: Contradictory results exist regarding the importance of early-life 
      exposure to phthalates for development of childhood eczema. OBJECTIVES: We 
      evaluated the association between maternal urinary concentrations of phthalate 
      metabolites between the 24th and 28th week of gestation and occurrence of eczema 
      in their sons up to 5 y of age, according to allergic sensitization as assessed 
      by total immunoglobulin E (IgE) in a subsample of individuals. METHODS: Data on 
      health outcomes and background factors were collected using five standardized 
      annual questionnaires completed by parents at the children's ages of 1-5 y, and 
      their associations with phthalate metabolite urinary concentrations were assessed 
      in 604 mother-son pairs with adjusted multiple logistic regression and Cox's 
      survival model. Several eczema phenotypes were considered. Atopic status was 
      assessed at 5 y of age in 293 boys through total IgE assessment. RESULTS: At 5 y 
      of age, the prevalence of ever eczema was 30.4%. Metabolites of di-isobutyl 
      phthalate (DiBP) and di-isononyl phthalate (DiNP) were positively associated with 
      early-onset (0-24 mo of age) eczema (15.7%) and late-onset (24-60 mo of age) 
      eczema (14.7%). Applying the Cox's model showed a significant association of 
      occurrence of eczema in the first 5 y of life with DiBP and DiNP metabolites. 
      Among IgE-sensitized boys, metabolites of di-n-butyl phthalate (DBP) and DiBP 
      were significantly associated with ever eczema hazard ratio (HR)=1.67 [95% 
      confidence interval (CI): 1.10, 2.54], p=0.01 and HR=1.87 (95% CI: 1.01, 3.48), 
      p=0.04, respectively. CONCLUSIONS: Occurrence of eczema in early childhood may 
      be influenced by prenatal exposure to certain phthalates in boys. Further 
      investigations are needed to confirm this observation. 
      https://doi.org/10.1289/EHP1829.
FAU - Soomro, Munawar Hussain
AU  - Soomro MH
AD  - Department of Epidemiology of Allergic and Respiratory Diseases (EPAR), 
      Saint-Antoine Medical School, Pierre Louis Institute of Epidemiology and Public 
      Health (IPLESP UMRS 1136), Institut national de la sante et de la recherche 
      medicale (Inserm), UPMC Universite Paris 06, Sorbonne Universites , Paris, 
      France.
AD  - Department of community Medicine, Al Nafees Medical College and Hospital, Isra 
      University-Islamabad Campus , Islamabad, Pakistan.
FAU - Baiz, Nour
AU  - Baiz N
AD  - Department of Epidemiology of Allergic and Respiratory Diseases (EPAR), 
      Saint-Antoine Medical School, Pierre Louis Institute of Epidemiology and Public 
      Health (IPLESP UMRS 1136), Institut national de la sante et de la recherche 
      medicale (Inserm), UPMC Universite Paris 06, Sorbonne Universites , Paris, 
      France.
FAU - Philippat, Claire
AU  - Philippat C
AD  - Team of Environmental Epidemiology applied to Reproduction and Respiratory 
      Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Universite 
      Grenoble Alpes, Grenoble, France.
FAU - Vernet, Celine
AU  - Vernet C
AD  - Team of Environmental Epidemiology applied to Reproduction and Respiratory 
      Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Universite 
      Grenoble Alpes, Grenoble, France.
FAU - Siroux, Valerie
AU  - Siroux V
AD  - Team of Environmental Epidemiology applied to Reproduction and Respiratory 
      Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Universite 
      Grenoble Alpes, Grenoble, France.
FAU - Nichole Maesano, Cara
AU  - Nichole Maesano C
AD  - Department of Epidemiology of Allergic and Respiratory Diseases (EPAR), 
      Saint-Antoine Medical School, Pierre Louis Institute of Epidemiology and Public 
      Health (IPLESP UMRS 1136), Institut national de la sante et de la recherche 
      medicale (Inserm), UPMC Universite Paris 06, Sorbonne Universites , Paris, 
      France.
FAU - Sanyal, Shreosi
AU  - Sanyal S
AD  - Department of Epidemiology of Allergic and Respiratory Diseases (EPAR), 
      Saint-Antoine Medical School, Pierre Louis Institute of Epidemiology and Public 
      Health (IPLESP UMRS 1136), Institut national de la sante et de la recherche 
      medicale (Inserm), UPMC Universite Paris 06, Sorbonne Universites , Paris, 
      France.
FAU - Slama, Remy
AU  - Slama R
AD  - Team of Environmental Epidemiology applied to Reproduction and Respiratory 
      Health, Institute for Advanced Biosciences (IAB), Inserm U1209, Universite 
      Grenoble Alpes, Grenoble, France.
FAU - Bornehag, Carl-Gustaf
AU  - Bornehag CG
AD  - Department of Health Sciences, Karlstad University , Karlstad, Sweden.
AD  - Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New 
      York, New York, USA.
FAU - Annesi-Maesano, Isabella
AU  - Annesi-Maesano I
AD  - Department of Epidemiology of Allergic and Respiratory Diseases (EPAR), 
      Saint-Antoine Medical School, Pierre Louis Institute of Epidemiology and Public 
      Health (IPLESP UMRS 1136), Institut national de la sante et de la recherche 
      medicale (Inserm), UPMC Universite Paris 06, Sorbonne Universites , Paris, 
      France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180202
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Phthalic Acids)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Environ Health Perspect. 2018 May 31;126(5):054001. PMID: 29856912
MH  - Age of Onset
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Eczema/*epidemiology/etiology/immunology
MH  - Environmental Exposure/*adverse effects
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Infant
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Phenotype
MH  - Phthalic Acids/*toxicity/urine
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*epidemiology/etiology/immunology
MH  - Prevalence
MH  - Prospective Studies
PMC - PMC6066334
EDAT- 2018/02/06 06:00
MHDA- 2019/01/22 06:00
PMCR- 2018/02/02
CRDT- 2018/02/06 06:00
PHST- 2017/03/01 00:00 [received]
PHST- 2017/12/21 00:00 [revised]
PHST- 2017/12/21 00:00 [accepted]
PHST- 2018/02/06 06:00 [entrez]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2019/01/22 06:00 [medline]
PHST- 2018/02/02 00:00 [pmc-release]
AID - EHP1829 [pii]
AID - 10.1289/EHP1829 [doi]
PST - epublish
SO  - Environ Health Perspect. 2018 Feb 2;126(2):027002. doi: 10.1289/EHP1829.