PMID- 29398668
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20180917
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 41
IP  - 4
DP  - 2018 Apr 1
TI  - Nardostachys jatamansi Ethanol Extract Ameliorates Abeta42 Cytotoxicity.
PG  - 470-477
LID - 10.1248/bpb.b17-00750 [doi]
AB  - The Nardostachys jatamansi DC (NJ) root has been used as a sedative or analgesic 
      to treat neurological symptoms and pain in traditional Korean medicine. Here, we 
      investigate the potential effects of NJ on Alzheimer's disease (AD) and reveal 
      the molecular mechanism through which NJ exerts its effects. The neuroprotective 
      effect of the NJ root ethanol extract against beta amyloid (Abeta) toxicity was 
      examined in vitro using a cell culture system and in vivo using a Drosophila AD 
      model. The NJ extract and chlorogenic acid, a major component of NJ, inhibited 
      Abeta-induced cell death in SH-SY5Y cells. Moreover, the NJ extract rescued the 
      neurological phenotypes of the Abeta42-expressing flies (decreased survival and 
      pupariation rate and a locomotor defect) and suppressed Abeta42-induced cell death 
      in the brain. We also found that NJ extract intake reduced glial cell number, 
      reactive oxygen species level, extracellular-signal-regulated kinase (ERK) 
      phosphorylation, and nitric oxide level in Abeta42-expressing flies, without 
      affecting Abeta accumulation. These data suggest that the neuroprotective activity 
      of NJ might be associated with its antioxidant and anti-inflammatory properties, 
      as well as its inhibitory action against ERK signaling; thus, NJ is a promising 
      medicinal plant for the development of AD treatment.
FAU - Liu, Quan Feng
AU  - Liu QF
AD  - Department of Oriental Medicine, Dongguk University.
AD  - Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, 
      Dongguk University.
FAU - Jeon, Youngjae
AU  - Jeon Y
AD  - Department of Biological Sciences, Konkuk University.
FAU - Sung, Yung-Wei
AU  - Sung YW
AD  - Department of Oriental Medicine, Dongguk University.
AD  - Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, 
      Dongguk University.
FAU - Lee, Jang Ho
AU  - Lee JH
AD  - Department of Biological Sciences, Konkuk University.
FAU - Jeong, Haemin
AU  - Jeong H
AD  - Department of Biological Sciences, Konkuk University.
FAU - Kim, Young-Mi
AU  - Kim YM
AD  - College of Pharmacy and Integrated Research Institute for Drug Development, 
      Dongguk University-Seoul.
FAU - Yun, Hye Sup
AU  - Yun HS
AD  - Department of Biological Sciences, Konkuk University.
FAU - Chin, Young-Won
AU  - Chin YW
AD  - College of Pharmacy and Integrated Research Institute for Drug Development, 
      Dongguk University-Seoul.
FAU - Jeon, Songhee
AU  - Jeon S
AD  - Dongguk University Research Institute of Biotechnology, Dongguk University.
AD  - Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical 
      Scientists at Chonnam National University.
FAU - Cho, Kyoung Sang
AU  - Cho KS
AD  - Department of Biological Sciences, Konkuk University.
FAU - Koo, Byung-Soo
AU  - Koo BS
AD  - Department of Oriental Medicine, Dongguk University.
AD  - Department of Oriental Neuropsychiatry, Graduate School of Oriental Medicine, 
      Dongguk University.
LA  - eng
PT  - Journal Article
DEP - 20180203
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Peptide Fragments)
RN  - 0 (Plant Extracts)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Alzheimer Disease/*drug therapy/metabolism/pathology
MH  - Amyloid beta-Peptides/antagonists & inhibitors/genetics/metabolism
MH  - Animals
MH  - Animals, Genetically Modified
MH  - Brain/*drug effects/metabolism/pathology
MH  - Cell Line
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Drosophila/genetics/growth & development
MH  - Ethnopharmacology
MH  - Humans
MH  - Larva/drug effects/metabolism
MH  - Medicine, Korean Traditional
MH  - Nardostachys/*chemistry
MH  - Nerve Tissue Proteins
MH  - Neurons/*drug effects/metabolism/pathology
MH  - Neuroprotective Agents/pharmacology/*therapeutic use
MH  - Peptide Fragments/antagonists & inhibitors/genetics/metabolism
MH  - Phytotherapy
MH  - Plant Extracts/pharmacology/*therapeutic use
MH  - Plant Roots/*chemistry
MH  - Republic of Korea
MH  - Survival Analysis
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Drosophila
OT  - Nardostachys jatamansi
OT  - anti-inflammation
OT  - antioxidant
OT  - extracellular-signal-regulated kinase
EDAT- 2018/02/06 06:00
MHDA- 2018/09/18 06:00
CRDT- 2018/02/06 06:00
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/02/06 06:00 [entrez]
AID - 10.1248/bpb.b17-00750 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2018 Apr 1;41(4):470-477. doi: 10.1248/bpb.b17-00750. Epub 2018 
      Feb 3.