PMID- 29399189
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210212
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 15
IP  - 2
DP  - 2018 Feb
TI  - MicroRNA-26b suppresses autophagy in breast cancer cells by targeting DRAM1 mRNA, 
      and is downregulated by irradiation.
PG  - 1435-1440
LID - 10.3892/ol.2017.7452 [doi]
AB  - MicroRNAs (miRs) are small RNAs that do not code for proteins, but instead 
      decrease the stability and suppress the translation of target mRNAs by binding 
      with complementary sequences in their 3'-untranslated regions (3'-UTRs). In the 
      present study, it is reported that breast cancer tumor tissue, as well as 
      irradiated MCF7 breast cancer cells, exhibit decreased levels of miR-26b 
      expression compared with normal breast tissue and MCF7 cells without exposure to 
      radiation. Additionally, a luciferase reporter assay was used to demonstrate that 
      miR-26b directly targetsDNA damage-regulated autophagy modulator 1 (DRAM1). MCF7 
      cells that were transfected with an miR-26b mimicexhibited the downregulated 
      expression of DRAM1 protein and a reduced level of irradiation-induced autophagy. 
      Inhibiting miR-26b resulted in the upregulation of DRAM1 and increased levels of 
      irradiation-induced autophagy in MCF7 cells. These results suggest that 
      therapeutic strategies to target miR-26b may increase the efficacy of certain 
      types of cancer therapy.
FAU - Meng, Cuida
AU  - Meng C
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
AD  - Department of Otolaryngology Head and Neck Surgery, China-Japan Union Hospital, 
      Jilin University, Changchun, Jilin 130033, P.R. China.
FAU - Liu, Yang
AU  - Liu Y
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Shen, Yannan
AU  - Shen Y
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Liu, Shuchun
AU  - Liu S
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Wang, Zhicheng
AU  - Wang Z
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Ye, Qingsheng
AU  - Ye Q
AD  - Medical Ultrasonic Engineering Department, Institute of Biomedical Engineering, 
      Chinese Academy of Medical Sciences, Tianjin 300192, P.R. China.
FAU - Liu, Hongyang
AU  - Liu H
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Liu, Xiaodong
AU  - Liu X
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
FAU - Jia, Lili
AU  - Jia L
AD  - Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, 
      Jilin University, Changchun, Jilin 130021, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20171121
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
EIN - Oncol Lett. 2021 Mar;21(3):199. PMID: 33574938
PMC - PMC5774516
OTO - NOTNLM
OT  - DNA damage-regulated autophagy modulator 1
OT  - autophagy
OT  - breast cancer
OT  - microRNA-26b
EDAT- 2018/02/06 06:00
MHDA- 2018/02/06 06:01
PMCR- 2017/11/21
CRDT- 2018/02/06 06:00
PHST- 2015/12/23 00:00 [received]
PHST- 2017/07/27 00:00 [accepted]
PHST- 2018/02/06 06:00 [entrez]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/02/06 06:01 [medline]
PHST- 2017/11/21 00:00 [pmc-release]
AID - OL-0-0-7452 [pii]
AID - 10.3892/ol.2017.7452 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Feb;15(2):1435-1440. doi: 10.3892/ol.2017.7452. Epub 2017 Nov 
      21.