PMID- 29400123
OWN - NLM
STAT- MEDLINE
DCOM- 20180823
LR  - 20180823
IS  - 1477-0962 (Electronic)
IS  - 0961-2033 (Linking)
VI  - 27
IP  - 3
DP  - 2018 Mar
TI  - Increased adhesion molecule levels in systemic lupus erythematosus: relationships 
      with severity of illness, autoimmunity, metabolic syndrome and cortisol levels.
PG  - 380-388
LID - 10.1177/0961203317723716 [doi]
AB  - Background This study was performed to assess adhesion molecules in systemic 
      lupus erythematosus (SLE). Methods This case-control study examined 126 SLE 
      patients and 48 healthy individuals. Blood levels of six adhesion molecules, 
      cortisol, nuclear autoantibody (ANA) and anti-double stranded DNA (anti-dsDNA) 
      titers were measured, while disease activity was assessed using the SLE Disease 
      Activity Index (SLEDAI) score. Results Platelet endothelial cell adhesion 
      molecule 1 (PECAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, 
      P-selectin, and plasminogen activator inhibitor type-1 (PAI-1) were significantly 
      higher in SLE patients than in controls. Binary logistic regression analysis 
      showed that PECAM-1 and PAI-1 predicted SLE with a sensitivity of 86.5% and a 
      specificity of 81.3%. ANA titers were significantly and positively associated 
      with PECAM-1, VCAM-1, E-selectin, and PAI-1, whereas there were no associations 
      between anti-dsDNA titers and adhesion molecules. Cortisol was negatively 
      associated with PCAM-1 and ICAM-1. There were significant associations between 
      metabolic syndrome (MetS) and E-selectin and PAI-1. 14.8% of the variance in the 
      SLEDAI score was explained by the regression on PECAM-1 and MetS. Conclusions Our 
      data show that adhesion molecules, especially PECAM-1, are significantly 
      associated with SLE and disease activity, suggesting that they play a role in SLE 
      pathophysiology. While MetS, ANA titers and cortisol levels modulate adhesion 
      molecule levels, these associations do not explain the increased levels of 
      adhesion molecules in SLE. Increased levels of adhesion molecules are new drug 
      targets in SLE.
FAU - da Rosa Franchi Santos, L F
AU  - da Rosa Franchi Santos LF
AD  - 1 Graduate Program in Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
FAU - Stadtlober, N P
AU  - Stadtlober NP
AD  - 1 Graduate Program in Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
FAU - Costa Dall'Aqua, L G
AU  - Costa Dall'Aqua LG
AD  - 1 Graduate Program in Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
FAU - Scavuzzi, B M
AU  - Scavuzzi BM
AD  - 2 Graduate Program in Health Sciences, University of Londrina, Brazil.
FAU - Guimaraes, P M
AU  - Guimaraes PM
AD  - 2 Graduate Program in Health Sciences, University of Londrina, Brazil.
FAU - Flauzino, T
AU  - Flauzino T
AD  - 2 Graduate Program in Health Sciences, University of Londrina, Brazil.
FAU - Batisti Lozovoy, M A
AU  - Batisti Lozovoy MA
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
FAU - Mayumi Iriyoda, T V
AU  - Mayumi Iriyoda TV
AD  - 4 Department of Rheumatology, University of Londrina, Brazil.
FAU - Vissoci Reiche, E M
AU  - Vissoci Reiche EM
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
FAU - Dichi, I
AU  - Dichi I
AD  - 5 Department of Internal Medicine, University of Londrina, Brazil.
FAU - Maes, M
AU  - Maes M
AD  - 6 IMPACT Strategic Research Centre, School of Medicine, Deakin University, 
      Geelong, VIC, Australia.
FAU - Colado Simao, A
AU  - Colado Simao A
AD  - 3 Department of Pathology, Clinical Analysis and Toxicology, University of 
      Londrina, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20180205
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (Cell Adhesion Molecules)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*blood
MH  - *Autoimmunity
MH  - Biomarkers/blood
MH  - Body Mass Index
MH  - Brazil
MH  - Case-Control Studies
MH  - Cell Adhesion Molecules/*blood
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Logistic Models
MH  - Lupus Erythematosus, Systemic/*blood/physiopathology
MH  - Male
MH  - Metabolic Syndrome/*complications
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - ANA
OT  - Systemic lupus erythematosus
OT  - adhesion molecules
OT  - body mass index
OT  - cortisol
OT  - metabolic syndrome
EDAT- 2018/02/06 06:00
MHDA- 2018/08/24 06:00
CRDT- 2018/02/06 06:00
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/08/24 06:00 [medline]
PHST- 2018/02/06 06:00 [entrez]
AID - 10.1177/0961203317723716 [doi]
PST - ppublish
SO  - Lupus. 2018 Mar;27(3):380-388. doi: 10.1177/0961203317723716. Epub 2018 Feb 5.