PMID- 29400347
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 2573-7902 (Electronic)
IS  - 2573-7899 (Print)
VI  - 1
IP  - 3
DP  - 2017 Dec 15
TI  - Effects of early trauma on psychosis development in clinical high-risk 
      individuals and stability of trauma assessment across studies: a review.
LID - 28 [pii]
AB  - Early trauma (ET), though broadly and inconsistently defined, has been repeatedly 
      linked to numerous psychological disturbances, including various developmental 
      stages of psychotic disorders. The prodromal phase of psychosis highlights a 
      unique and relevant population that provides insight into the critical periods of 
      psychosis development. As such, a relatively recent research focus on individuals 
      at clinical high risk (CHR) for psychosis reveals robust associations of early 
      life trauma exposures with prodromal symptoms and function in these cohorts. 
      While prevalence rates of ET in CHR cohorts remain consistently high, 
      methodological measures of traumatic experiences vary across studies, presenting 
      potential problems for reliability and validity of results. This review aims to 
      1) highlight the existing evidence identifying associations of ET, of multiple 
      forms, with both symptom severity and transition rates to psychosis in CHR 
      individuals, 2) present data on the variability among trauma assessments and its 
      implications for conclusions about its relationship with clinical variables, 3) 
      describe cognitive deficits common in CHR cohorts, including perceptual and 
      neurocognitive impairments, and their neural correlates, that may modify the 
      relationship of ET to symptoms, and 4) propose future directions for 
      standardization of trauma assessment in CHR cohorts to better understand its 
      clinical and cognitive correlates.
FAU - Redman, Samantha L
AU  - Redman SL
AD  - Icahn School of Medicine at Mount Sinai, New York, New York, USA.
FAU - Corcoran, Cheryl M
AU  - Corcoran CM
AD  - Icahn School of Medicine at Mount Sinai, New York, New York, USA.
FAU - Kimhy, David
AU  - Kimhy D
AD  - Icahn School of Medicine at Mount Sinai, New York, New York, USA.
FAU - Malaspina, Dolores
AU  - Malaspina D
AD  - Icahn School of Medicine at Mount Sinai, New York, New York, USA.
LA  - eng
GR  - R01 MH107558/MH/NIMH NIH HHS/United States
GR  - R01 MH110418/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - Arch Psychol (Chic)
JT  - Archives of psychology (Chicago, Ill.)
JID - 101719080
PMC - PMC5791764
MID - NIHMS930380
OTO - NOTNLM
OT  - Clinical High Risk
OT  - Early Trauma
OT  - Psychosis
OT  - Trauma Assessment
EDAT- 2018/02/06 06:00
MHDA- 2018/02/06 06:01
PMCR- 2018/01/31
CRDT- 2018/02/06 06:00
PHST- 2018/02/06 06:00 [entrez]
PHST- 2018/02/06 06:00 [pubmed]
PHST- 2018/02/06 06:01 [medline]
PHST- 2018/01/31 00:00 [pmc-release]
AID - 28 [pii]
PST - ppublish
SO  - Arch Psychol (Chic). 2017 Dec 15;1(3):28. Epub 2017 Dec 18.