PMID- 29401579
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 32
IP  - 5
DP  - 2018 May
TI  - Excess maternal fructose consumption impairs hippocampal function in offspring 
      via epigenetic modification of BDNF promoter.
PG  - 2549-2562
LID - 10.1096/fj.201700783RR [doi]
AB  - Recent increases in fructose consumption have raised concerns about the potential 
      adverse intergenerational effects of excess fructose intake. In the present 
      study, we investigated whether excess maternal fructose intake affects 
      hippocampal function in offspring. Female Sprague-Dawley rats were divided into 3 
      experimental groups: one group received distilled water, one group received 20% 
      fructose water, and one group received 20% glucose water in addition to standard 
      chow during gestation and lactation. Hippocampal function of offspring was 
      evaluated by using novel object recognition and fear conditioning tests. Impaired 
      cognitive performance was observed in the offspring of fructose-fed dams at 
      postnatal d 60, potentially a result of decreased hippocampal neurogenesis. 
      Real-time PCR analysis demonstrated that offspring from fructose-fed dams 
      exhibited decreased brain-derived neurotrophic factor ( BDNF) gene expression, 
      whereas pyrosequencing assays revealed increased DNA methylation at the BDNF 
      promoter. The potential association between BDNF transcription and levels of DNA 
      methylation was confirmed on the basis of luciferase activity. Furthermore, 
      longitudinal analysis revealed that increased methylation of the BDNF promoter 
      region was maintained at least until rats reached maturity. These results 
      indicate that epigenetic changes associated with BDNF may underlie hippocampal 
      dysfunction that is induced by early-life exposure to excess maternal fructose 
      consumption.-Yamazaki, M., Yamada, H., Munetsuna, E., Ishikawa, H., Mizuno, G., 
      Mukuda, T., Mouri, A., Nabeshima, T., Saito, K., Suzuki, K., Hashimoto, S., 
      Ohashi, K. Excess maternal fructose consumption impairs hippocampal function in 
      offspring via epigenetic modification of BDNF promoter.
FAU - Yamazaki, Mirai
AU  - Yamazaki M
AD  - Department of Clinical Biochemistry, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Yamada, Hiroya
AU  - Yamada H
AD  - Department of Hygiene, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
FAU - Munetsuna, Eiji
AU  - Munetsuna E
AD  - Department of Biochemistry, School of Medicine, Fujita Health University, 
      Toyoake, Japan.
FAU - Ishikawa, Hiroaki
AU  - Ishikawa H
AD  - Department of Clinical Biochemistry, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Mizuno, Genki
AU  - Mizuno G
AD  - Department of Clinical Biochemistry, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Mukuda, Takao
AU  - Mukuda T
AD  - Department of Anatomy, Faculty of Medicine, Tottori University, Yonago, Japan.
FAU - Mouri, Akihiro
AU  - Mouri A
AD  - Advanced Diagnostic System Research Laboratory, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Nabeshima, Toshitaka
AU  - Nabeshima T
AD  - Advanced Diagnostic System Research Laboratory, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Saito, Kuniaki
AU  - Saito K
AD  - Department of Disease Control and Prevention, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
FAU - Suzuki, Koji
AU  - Suzuki K
AD  - Department of Preventive Medical Sciences, School of Health Sciences, School of 
      Medicine, Fujita Health University, Toyoake, Japan.
FAU - Hashimoto, Shuji
AU  - Hashimoto S
AD  - Department of Hygiene, School of Medicine, Fujita Health University, Toyoake, 
      Japan.
FAU - Ohashi, Koji
AU  - Ohashi K
AD  - Department of Clinical Biochemistry, School of Medicine, Fujita Health 
      University, Toyoake, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180108
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - DNA Methylation/drug effects
MH  - Epigenesis, Genetic/*drug effects
MH  - Female
MH  - Fructose/*adverse effects/pharmacology
MH  - Hippocampus/*metabolism/pathology
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism/pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - DOHaD
OT  - cognitive function
OT  - early-life adversity
OT  - maternal nutrition
EDAT- 2018/02/07 06:00
MHDA- 2019/01/08 06:00
CRDT- 2018/02/07 06:00
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - 10.1096/fj.201700783RR [doi]
PST - ppublish
SO  - FASEB J. 2018 May;32(5):2549-2562. doi: 10.1096/fj.201700783RR. Epub 2018 Jan 8.