PMID- 29401584
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
DP  - 2018 Jan 11
TI  - RETRACTED: Deficiency of a novel gene, Yulink, predisposes to heart failure and 
      ventricular arrhythmia.
PG  - fj201700932RR
LID - 10.1096/fj.201700932RR [doi]
AB  - Heart failure is a major cardiovascular disease and is associated with 
      significant morbidity and mortality. Sudden cardiac death (SCD) in heart failure 
      is a disastrous cardiovascular phenomenon. However, few studies have examined the 
      genetic background that determines susceptibility to heart failure and SCD. We 
      found that deficiency of a newly identified gene, Yulink, promoted cardiac 
      alternans in zebrafish cardiomyocytes, and genetic knockdown (KD) resulted in 
      pericardial edema, decreased cardiac output, and premature ventricular 
      contractions. Yulink KD morphants exhibited irregular action potentials, slower 
      Ca(2+) reuptake, and alternans of Ca(2+) transients and action potential 
      duration, which are hallmarks for SCD susceptibility in heart failure. Similarly, 
      KD of Yulink in mouse cardiomyocytes disrupted Ca(2+) reuptake, reduced the 
      expression of cardiac Serca2, and resulted in a reduction in peroxisome 
      proliferator-activated receptor (PPAR)gamma activity. Expression of Serca2 was 
      up-regulated by PPARgamma agonists and down-regulated by PPARgamma-short hairpin RNA KD, 
      suggesting that Yulink regulates Serca2 expression through PPARgamma. Finally, Yulink 
      and Serca2 were down-regulated in ventricular samples of hearts from patients 
      with heart failure due to dilated cardiomyopathy. Our results highlight the 
      interaction of Yulink with PPARgamma in regulating Serca2 expression and suggest a 
      mechanistic role of the Yulink in the development of human heart failure and 
      SCD.-Tsai, C.-T., Kuo, M.-W., Lin, J.-L., Yu, A. L., Yu, J. Deficiency of a novel 
      gene, Yulink, predisposes to heart failure and ventricular arrhythmia.
FAU - Tsai, Chia-Ti
AU  - Tsai CT
AD  - Division of Cardiology, Department of Internal Medicine, National Taiwan 
      University Hospital, Taipei, Taiwan.
FAU - Kuo, Ming-Wei
AU  - Kuo MW
AD  - Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial 
      Hospital at Linkou, Taoyuan, Taiwan.
FAU - Lin, Jiunn-Lee
AU  - Lin JL
AD  - Division of Cardiology, Department of Internal Medicine, National Taiwan 
      University Hospital, Taipei, Taiwan.
FAU - Yu, Alice L
AU  - Yu AL
AD  - Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial 
      Hospital at Linkou, Taoyuan, Taiwan.
AD  - Department of Pediatrics, University of California, San Diego, California, USA.
FAU - Yu, John
AU  - Yu J
AD  - Institute of Stem Cell and Translational Cancer Research, Chang Gung Memorial 
      Hospital at Linkou, Taoyuan, Taiwan.
AD  - Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20180111
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RIN - FASEB J. 2018 Apr;32(4):2316. PMID: 29592790
OTO - NOTNLM
OT  - PPARgamma
OT  - Serca2
OT  - alternans
EDAT- 2018/02/07 06:00
MHDA- 2018/02/07 06:00
CRDT- 2018/02/07 06:00
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/02/07 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - 10.1096/fj.201700932RR [doi]
PST - aheadofprint
SO  - FASEB J. 2018 Jan 11:fj201700932RR. doi: 10.1096/fj.201700932RR.