PMID- 29401600
OWN - NLM
STAT- MEDLINE
DCOM- 20190115
LR  - 20190115
IS  - 1530-6860 (Electronic)
IS  - 0892-6638 (Linking)
VI  - 32
IP  - 6
DP  - 2018 Jun
TI  - High dietary fat intake increases fat oxidation and reduces skeletal muscle 
      mitochondrial respiration in trained humans.
PG  - 2979-2991
LID - 10.1096/fj.201700993R [doi]
AB  - High-fat, low-carbohydrate (CHO) diets increase whole-body rates of fat oxidation 
      and down-regulate CHO metabolism. We measured substrate utilization and skeletal 
      muscle mitochondrial respiration to determine whether these adaptations are 
      driven by high fat or low CHO availability. In a randomized crossover design, 8 
      male cyclists consumed 5 d of a high-CHO diet [>70% energy intake (EI)], followed 
      by 5 d of either an isoenergetic high-fat (HFAT; >65% EI) or high-protein diet 
      (HPRO; >65% EI) with CHO intake clamped at <20% EI. During the intervention, 
      participants undertook daily exercise training. On d 6, participants consumed a 
      high-CHO diet before performing 100 min of submaximal steady-state cycling plus 
      an  approximately 30-min time trial. After 5 d of HFAT, skeletal muscle mitochondrial 
      respiration supported by octanoylcarnitine and pyruvate, as well as uncoupled 
      respiration, was decreased at rest, and rates of whole-body fat oxidation were 
      higher during exercise compared with HPRO. After 1 d of high-CHO diet intake, 
      mitochondrial respiration returned to baseline values in HFAT, whereas rates of 
      substrate oxidation returned toward baseline in both conditions. These findings 
      demonstrate that high dietary fat intake, rather than low-CHO intake, contributes 
      to reductions in mitochondrial respiration and increases in whole-body rates of 
      fat oxidation after a consuming a high-fat, low-CHO diet.-Leckey, J. J., Hoffman, 
      N. J., Parr, E. B., Devlin, B. L., Trewin, A. J., Stepto, N. K., Morton, J. P., 
      Burke, L. M., Hawley, J. A. High dietary fat intake increases fat oxidation and 
      reduces skeletal muscle mitochondrial respiration in trained humans.
FAU - Leckey, Jill J
AU  - Leckey JJ
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
FAU - Hoffman, Nolan J
AU  - Hoffman NJ
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
FAU - Parr, Evelyn B
AU  - Parr EB
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
FAU - Devlin, Brooke L
AU  - Devlin BL
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
FAU - Trewin, Adam J
AU  - Trewin AJ
AD  - Institute of Sport, Exercise, and Active Living, Victoria University, College of 
      Sport and Exercise Science, Melbourne, Victoria, Australia.
FAU - Stepto, Nigel K
AU  - Stepto NK
AD  - Institute of Sport, Exercise, and Active Living, Victoria University, College of 
      Sport and Exercise Science, Melbourne, Victoria, Australia.
FAU - Morton, James P
AU  - Morton JP
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool, United Kingdom.
FAU - Burke, Louise M
AU  - Burke LM
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
AD  - Australian Institute of Sport, Canberra, Australian Capital Territory, Australia.
FAU - Hawley, John A
AU  - Hawley JA
AD  - Mary MacKillop Institute for Health Research, Australian Catholic University, 
      Melbourne, Victoria, Australia.
AD  - Research Institute for Sport and Exercise Sciences, Liverpool John Moores 
      University, Liverpool, United Kingdom.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180117
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Dietary Fats)
SB  - IM
MH  - Adult
MH  - Diet, Carbohydrate-Restricted
MH  - Dietary Fats/*administration & dosage
MH  - Exercise/*physiology
MH  - Humans
MH  - Male
MH  - Mitochondria, Muscle/*metabolism
MH  - Muscle, Skeletal/*metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Oxygen Consumption/*drug effects
OTO - NOTNLM
OT  - adaptation
OT  - carbohydrate
OT  - exercise
OT  - metabolism
OT  - substrate utilization
EDAT- 2018/02/07 06:00
MHDA- 2019/01/16 06:00
CRDT- 2018/02/07 06:00
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2019/01/16 06:00 [medline]
PHST- 2018/02/07 06:00 [entrez]
AID - 10.1096/fj.201700993R [doi]
PST - ppublish
SO  - FASEB J. 2018 Jun;32(6):2979-2991. doi: 10.1096/fj.201700993R. Epub 2018 Jan 17.