PMID- 29403537
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2017
DP  - 2017
TI  - Dai-Huang-Fu-Zi-Tang Alleviates Intestinal Injury Associated with Severe Acute 
      Pancreatitis by Regulating Mitochondrial Permeability Transition Pore of 
      Intestinal Mucosa Epithelial Cells.
PG  - 4389048
LID - 10.1155/2017/4389048 [doi]
LID - 4389048
AB  - OBJECTIVE: The aim of the present study was to examine whether 
      Dai-Huang-Fu-Zi-Tang (DHFZT) could regulate mitochondrial permeability transition 
      pore (MPTP) of intestinal mucosa epithelial cells for alleviating intestinal 
      injury associated with severe acute pancreatitis (SAP). METHODS: A total of 72 
      Sprague-Dawley rats were randomly divided into 3 groups (sham group, SAP group, 
      and DHFZT group, n = 24 per group). The rats in each group were divided into 4 
      subgroups (n = 6 per subgroup) accordingly at 1, 3, 6, and 12 h after the 
      operation. The contents of serum amylase, D-lactic acid, diamine oxidase 
      activity, and degree of MPTP were measured by dry chemical method and 
      enzyme-linked immunosorbent assay. The change of mitochondria of intestinal 
      epithelial cells was observed by transmission electron microscopy. RESULTS: The 
      present study showed that DHFZT inhibited the openness of MPTP at 3, 6, and 12 h 
      after the operation. Meanwhile, it reduced the contents of serum D-lactic acid 
      and activity of diamine oxidase activity and also drastically relieved 
      histopathological manifestations and epithelial cells injury of intestine. 
      CONCLUSION: DHFZT alleviates intestinal injury associated SAP via reducing the 
      openness of MPTP. In addition, DHFZT could also decrease the content of serum 
      diamine oxidase activity and D-lactic acid after SAP.
FAU - Kang, Xin
AU  - Kang X
AD  - Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 
      116001, China.
FAU - Liang, Zhengkai
AU  - Liang Z
AD  - Gastrointestinal Surgery, Liaocheng City People's Hospital, Liaocheng 252000, 
      China.
FAU - Lu, Xiaoguang
AU  - Lu X
AUID- ORCID: 0000-0001-8741-9928
AD  - Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 
      116001, China.
FAU - Zhan, Libin
AU  - Zhan L
AD  - Basic Medical College, Nanjing University of Chinese Medicine, Nanjing 210023, 
      China.
FAU - Song, Jianbo
AU  - Song J
AD  - Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 
      116001, China.
FAU - Wang, Yi
AU  - Wang Y
AD  - Graduate School, Dalian Medical University, Dalian 116044, China.
FAU - Yang, Yilun
AU  - Yang Y
AD  - Graduate Schools, Zunyi Medical College, Zunyi 563003, China.
FAU - Fan, Zhiwei
AU  - Fan Z
AD  - Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 
      116001, China.
FAU - Bai, Lizhi
AU  - Bai L
AD  - Department of Emergency Medicine, Zhongshan Hospital, Dalian University, Dalian 
      116001, China.
LA  - eng
PT  - Journal Article
DEP - 20171218
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC5748303
EDAT- 2018/02/07 06:00
MHDA- 2018/02/07 06:01
PMCR- 2017/12/18
CRDT- 2018/02/07 06:00
PHST- 2017/07/18 00:00 [received]
PHST- 2017/11/21 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/02/07 06:01 [medline]
PHST- 2017/12/18 00:00 [pmc-release]
AID - 10.1155/2017/4389048 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2017;2017:4389048. doi: 10.1155/2017/4389048. 
      Epub 2017 Dec 18.