PMID- 29403645
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220311
IS  - 2051-6673 (Print)
IS  - 2051-6673 (Electronic)
IS  - 2051-6673 (Linking)
VI  - 5
DP  - 2018
TI  - Impact of prenatal stress on mother-infant dyadic behavior during the still-face 
      paradigm.
PG  - 2
LID - 10.1186/s40479-018-0078-8 [doi]
LID - 2
AB  - BACKGROUND: Mother-infant interaction provides important training for the 
      infant's ability to cope with stress and the development of resilience. Prenatal 
      stress (PS) and its impact on the offspring's development have long been a focus 
      of stress research, with studies highlighting both harmful and beneficial 
      effects. The aim of the current study was to examine the possible influence of 
      both psychological stress and hypothalamic-pituitary-adrenal (HPA) axis activity 
      during pregnancy with mother-child dyadic behavior following stress exposure. 
      METHODS: The behavior of 164 mother-infant dyads during the still-face situation 
      was filmed at six months postpartum and coded into three dyadic patterns: 1) both 
      positive, 2) infant protesting-mother positive, and 3) infant protesting-mother 
      negative. PS exposure was assessed prenatally according to psychological measures 
      (i.e., psychopathological, perceived and psychosocial PS; n = 164) and HPA axis 
      activity measures (maternal salivary cortisol, i.e., cortisol decline and area 
      under the curve with respect to ground (AUCg); n = 134). RESULTS: Mother-infant 
      dyads in both the high- and low-stress groups showed decreasing positive and 
      increasing negative dyadic behavior in the reunion episode, which is associated 
      with the well-known "still-face" and "carry-over" effect. Furthermore, 
      mother-infant dyads with higher psychosocial PS exhibited significantly more 
      positive dyadic behavior than the low psychosocial PS group in the first play 
      episode, but not in the reunion episode. Similarly, mother-infant dyads with high 
      HPA axis activity (i.e. high AUCg) but steeper diurnal cortisol decline (i.e. 
      cortisol decline) displayed significantly less negative behavior in the reunion 
      episode than dyads with low HPA axis activity. No significant results were found 
      for psychopathological stress and perceived stress. CONCLUSIONS: The results 
      suggest a beneficial effect of higher psychosocial PS and higher prenatal 
      maternal HPA axis activity in late gestation, which is in line with "stress 
      inoculation" theories.
FAU - Wolf, Isabell Ann-Cathrin
AU  - Wolf IA
AD  - 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Gilles, Maria
AU  - Gilles M
AD  - 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Peus, Verena
AU  - Peus V
AD  - 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Scharnholz, Barbara
AU  - Scharnholz B
AD  - 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Seibert, Julia
AU  - Seibert J
AD  - Clinic for General Psychiatry, Center for Psychosocial Medicine, Heidelberg 
      University Hospital, University of Heidelberg, Heidelberg, Germany.
FAU - Jennen-Steinmetz, Christine
AU  - Jennen-Steinmetz C
AD  - 3Department of Biostatistics, Central Institute of Mental Health, Medical Faculty 
      Mannheim, University of Heidelberg, Mannheim, Germany. ISNI: 0000 0004 0477 2235. 
      GRID: grid.413757.3
FAU - Krumm, Bertram
AU  - Krumm B
AD  - 3Department of Biostatistics, Central Institute of Mental Health, Medical Faculty 
      Mannheim, University of Heidelberg, Mannheim, Germany. ISNI: 0000 0004 0477 2235. 
      GRID: grid.413757.3
FAU - Rietschel, Marcella
AU  - Rietschel M
AD  - 4Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental 
      Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Deuschle, Michael
AU  - Deuschle M
AD  - 1Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, 
      Medical Faculty Mannheim / Heidelberg University, J 5, 68159 Mannheim, Germany. 
      ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
FAU - Laucht, Manfred
AU  - Laucht M
AD  - 5Department of Child and Adolescent Psychiatry and Psychotherapy, Central 
      Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, 
      Mannheim, Germany. ISNI: 0000 0004 0477 2235. GRID: grid.413757.3
AD  - 6Department of Psychology, University of Potsdam, Potsdam, Germany. ISNI: 0000 
      0001 0942 1117. GRID: grid.11348.3f
LA  - eng
PT  - Journal Article
DEP - 20180122
PL  - England
TA  - Borderline Personal Disord Emot Dysregul
JT  - Borderline personality disorder and emotion dysregulation
JID - 101650634
PMC - PMC5778796
OTO - NOTNLM
OT  - Cortisol
OT  - Face-to-face still-face paradigm
OT  - Prenatal stress
OT  - Psychosocial stress
OT  - Resilience
COIS- The study protocol was approved by the Ethics Committee of the Medical Faculty 
      Mannheim of the University of Heidelberg and the Ethics Committee of the Medical 
      Association of Rhineland-Palatinate and conducted in accordance with the 
      Declaration of Helsinki. All mothers provided written informed consent prior to 
      enrolment in the study.All mothers participating in the still-face situation gave 
      their written consent to the filming and later pseudonymized analyses.Michael 
      Deuschle and his research group received speaker and consulting fees from 
      BristolMyers Squibb, Lundbeck Otsuka Pharma, and Servier. Michael Deuschle is a 
      national coordinator and principal investigator of phase II and III trials for 
      Lilly Pharma and Roche. The remaining co-authors have no competing interests to 
      declare.Springer Nature remains neutral with regard to jurisdictional claims in 
      published maps and institutional affiliations.
EDAT- 2018/02/07 06:00
MHDA- 2018/02/07 06:01
PMCR- 2018/01/22
CRDT- 2018/02/07 06:00
PHST- 2017/08/30 00:00 [received]
PHST- 2018/01/03 00:00 [accepted]
PHST- 2018/02/07 06:00 [entrez]
PHST- 2018/02/07 06:00 [pubmed]
PHST- 2018/02/07 06:01 [medline]
PHST- 2018/01/22 00:00 [pmc-release]
AID - 78 [pii]
AID - 10.1186/s40479-018-0078-8 [doi]
PST - epublish
SO  - Borderline Personal Disord Emot Dysregul. 2018 Jan 22;5:2. doi: 
      10.1186/s40479-018-0078-8. eCollection 2018.